他汀类药物治疗可减少腹主动脉瘤的生长。
Statin therapy reduces growth of abdominal aortic aneurysms.
机构信息
Department of Internal Medicine, The University of Iowa, Iowa City, IA, USA.
出版信息
J Investig Med. 2011 Dec;59(8):1239-43. doi: 10.2130/JIM.0b013e31823548e8.
Abstract
BACKGROUND
The aim of this study was to evaluate the influence of statins on the growth of small abdominal aortic aneurysms (AAAs).
METHODS
We retrospectively examined AAA diameter in 211 patients who had undergone serial imaging surveillance.
RESULTS
Patients treated with and without statins were similar regarding age, initial aneurysm size, diagnosis of diabetes and hypertension, and smoking history. Patients receiving statins had a decreased aneurysm growth rate compared with those patients not receiving statins (0.9 mm/y [interquartile range, -1.0 to +1.0] vs 3.2 mm/y [interquartile range, 2.0-4.9], P < 0.0001). This difference in the rate of growth was maintained after adjusting for potential confounding factors.
CONCLUSIONS
To date, this is the one of the largest retrospective studies demonstrating an association between statin use and decreased growth rate of AAA.
摘要
背景
本研究旨在评估他汀类药物对小的腹主动脉瘤（AAA）生长的影响。
方法
我们回顾性地检查了 211 名接受连续影像学监测的患者的 AAA 直径。
结果
接受他汀类药物治疗和未接受他汀类药物治疗的患者在年龄、初始动脉瘤大小、糖尿病和高血压诊断以及吸烟史方面相似。与未服用他汀类药物的患者相比，服用他汀类药物的患者的动脉瘤生长速度较慢（0.9 毫米/年[四分位距，-1.0 至+1.0]与 3.2 毫米/年[四分位距，2.0-4.9]，P < 0.0001）。在调整了潜在的混杂因素后，这种生长速度的差异仍然存在。
结论
迄今为止，这是最大的回顾性研究之一，表明他汀类药物的使用与 AAA 生长速度减慢之间存在关联。
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