Signaling and Transcription Laboratory, Department of Gastroenterology, Philipps-University of Marburg, Marburg, Germany.
Gut. 2013 Feb;62(2):310-6. doi: 10.1136/gutjnl-2011-301008. Epub 2011 Oct 13.
Transcription factors are proteins that regulate gene expression by modulating the synthesis of messenger RNA. Since this process is often one dominant control point in the production of many proteins, transcription factors represent the key regulators of numerous cellular functions, including proliferation, differentiation and apoptosis. Pancreatic cancer progression is characterised by activation of inflammatory signalling pathways converging on a limited set of transcription factors that fine-tune gene expression patterns contributing to the growth and maintenance of these tumours. Thus strategies targeting these transcriptional networks activated in pancreatic cancer cells could block the effects of upstream inflammatory responses participating in pancreatic tumorigenesis. The authors review this field of research and summarise current strategies for targeting oncogenic transcription factors and their activating signalling networks in the treatment of pancreatic cancer.
转录因子是通过调节信使 RNA 的合成来调节基因表达的蛋白质。由于这个过程通常是许多蛋白质产生的一个主要控制点，转录因子是许多细胞功能的关键调节剂，包括增殖、分化和凋亡。胰腺癌的进展的特点是炎症信号通路的激活，这些信号通路汇聚到一组有限的转录因子上，这些转录因子微调基因表达模式，有助于这些肿瘤的生长和维持。因此，针对这些在胰腺癌细胞中激活的转录网络的策略可以阻断参与胰腺肿瘤发生的上游炎症反应的影响。作者回顾了这一研究领域，并总结了目前针对致癌转录因子及其激活信号网络的治疗胰腺癌的策略。
