Department of Psychiatry, Psychosomatics, and Psychotherapy, University Hospital Wuerzburg, Germany.
Hum Brain Mapp. 2013 Jan;34(1):150-7. doi: 10.1002/hbm.21421. Epub 2011 Oct 14.
Recent studies highlighted the great potential of newly established theta burst stimulation (TBS) protocols for non-invasive human brain stimulation studies using transcranial magnetic stimulation (TMS). While intermittent TBS over the primary motor cortex was found to potentiate motor evoked potentials, continuous TBS led to profound attenuations. Although numerous studies investigated the impact of TBS on motor cortex function, yet, only few imaging studies focused on its effects in other brain areas. Particularly for the prefrontal cortex, it is unclear whether TBS has similar effects compared to application over motor areas. In the current study continuous TBS was applied to either the left or right dorsolateral prefrontal cortex in a sample of healthy subjects. Changes in prefrontal oxygenation were measured during an emotional Stroop task by means of functional multi-channel near-infrared spectroscopy (fNIRS) before and after stimulation. Results showed bilaterally decreased prefrontal oxygenation following inhibitory stimulation of the left prefrontal cortex but no behavioral effect. No such alterations were observed following right-hemispheric or sham stimulation. The results of the current study are in line with earlier findings and additionally demonstrate that also prefrontal oxygenation can be impaired by continuous TBS.
最近的研究强调了新建立的 theta 爆发刺激 (TBS) 方案在使用经颅磁刺激 (TMS) 的非侵入性人类大脑刺激研究中的巨大潜力。虽然初级运动皮层的间歇 TBS 被发现可增强运动诱发电位，但连续 TBS 则导致深度衰减。尽管许多研究调查了 TBS 对运动皮层功能的影响，但只有少数成像研究关注其对其他脑区的影响。特别是对于前额叶皮层，尚不清楚 TBS 是否具有与运动区应用相似的效果。在当前的研究中，连续 TBS 被应用于健康受试者的左侧或右侧背外侧前额叶皮层。通过功能性多通道近红外光谱 (fNIRS) 在刺激前后测量情绪 Stroop 任务期间前额叶的氧合变化。结果显示，左侧前额叶抑制性刺激后双侧前额叶氧合降低，但无行为效应。右侧半球或假刺激后未观察到这种变化。当前研究的结果与早期研究结果一致，此外还表明连续 TBS 也可损害前额叶氧合。
