Chung Sung Wook, Lewis Benjamin P, Rogasch Nigel C, Saeki Takashi, Thomson Richard H, Hoy Kate E, Bailey Neil W, Fitzgerald Paul B
Monash Alfred Psychiatry Research Centre, Monash University, Central Clinical School and The Alfred, Melbourne, Australia.
Monash Alfred Psychiatry Research Centre, Monash University, Central Clinical School and The Alfred, Melbourne, Australia.
Clin Neurophysiol. 2017 Jul;128(7):1117-1126. doi: 10.1016/j.clinph.2017.04.005. Epub 2017 Apr 24.
To examine the effects of intermittent TBS (iTBS) and continuous TBS (cTBS) on cortical reactivity in the dorsolateral prefrontal cortex.
10 healthy participants were stimulated with either iTBS, cTBS or sham at F3 electrode. Single- and paired-pulse TMS and concurrent electroencephalography (EEG) were used to assess change in cortical reactivity and long-interval intracortical inhibition (LICI) via TMS-evoked potentials (TEPs) and TMS-evoked oscillations.
Significant increases in N120 amplitudes (p<0.01) were observed following iTBS over prefrontal cortex. Changes in TMS-evoked theta oscillations and LICI of theta oscillations were also observed following iTBS (increase) and cTBS (decrease). Change in LICI of theta oscillations correlated with change in N120 amplitude following TBS (r=-0.670, p=0.001).
This study provides preliminary evidence that TBS produces direct changes in cortical reactivity in the prefrontal cortex. Combining TBS with TMS-EEG may be a useful approach to optimise stimulation paradigms prior to the conduct of clinical trials.
TBS is able to modulate cortical reactivity and cortical inhibition in the prefrontal cortex.
研究间歇性重复经颅磁刺激（iTBS）和连续性重复经颅磁刺激（cTBS）对背外侧前额叶皮质皮质反应性的影响。
10名健康受试者在F3电极处接受iTBS、cTBS或假刺激。采用单脉冲和双脉冲经颅磁刺激（TMS）以及同步脑电图（EEG），通过TMS诱发电位（TEP）和TMS诱发振荡来评估皮质反应性和长时程皮质内抑制（LICI）的变化。
iTBS刺激前额叶皮质后，观察到N120波幅显著增加（p<0.01）。iTBS（增加）和cTBS（降低）后也观察到TMS诱发的θ振荡和θ振荡的LICI变化。θ振荡的LICI变化与TBS后N120波幅变化相关（r=-0.670，p=0.001）。
本研究提供了初步证据，表明TBS可使前额叶皮质的皮质反应性产生直接变化。在开展临床试验之前，将TBS与TMS-EEG相结合可能是优化刺激方案的一种有用方法。
TBS能够调节前额叶皮质的皮质反应性和皮质抑制。
