巨噬细胞亚群的保护和致病功能。
Protective and pathogenic functions of macrophage subsets.
机构信息
Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.
出版信息
Nat Rev Immunol. 2011 Oct 14;11(11):723-37. doi: 10.1038/nri3073.
Abstract
Macrophages are strategically located throughout the body tissues, where they ingest and process foreign materials, dead cells and debris and recruit additional macrophages in response to inflammatory signals. They are highly heterogeneous cells that can rapidly change their function in response to local microenvironmental signals. In this Review, we discuss the four stages of orderly inflammation mediated by macrophages: recruitment to tissues; differentiation and activation in situ; conversion to suppressive cells; and restoration of tissue homeostasis. We also discuss the protective and pathogenic functions of the various macrophage subsets in antimicrobial defence, antitumour immune responses, metabolism and obesity, allergy and asthma, tumorigenesis, autoimmunity, atherosclerosis, fibrosis and wound healing. Finally, we briefly discuss the characterization of macrophage heterogeneity in humans.
摘要
巨噬细胞在全身组织中战略性分布，吞噬和处理外来物质、死亡细胞和碎片，并在炎症信号的刺激下招募更多的巨噬细胞。它们是高度异质性的细胞，可以根据局部微环境信号迅速改变其功能。在这篇综述中，我们讨论了巨噬细胞介导的有序炎症的四个阶段：招募到组织；在原位分化和激活；转化为抑制性细胞；以及恢复组织内稳态。我们还讨论了各种巨噬细胞亚群在抗菌防御、抗肿瘤免疫反应、代谢和肥胖、过敏和哮喘、肿瘤发生、自身免疫、动脉粥样硬化、纤维化和伤口愈合中的保护和致病功能。最后，我们简要讨论了人类巨噬细胞异质性的特征。
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