巨噬细胞介导体内炎症与代谢疾病。
Macrophage-mediated inflammation in metabolic disease.
机构信息
Cardiovascular Research Institute, University of California San Francisco, California 94158-9001, USA.
出版信息
Nat Rev Immunol. 2011 Oct 10;11(11):738-49. doi: 10.1038/nri3071.
Abstract
Metabolism and immunity are two fundamental systems of metazoans. The presence of immune cells, such as macrophages, in metabolic tissues suggests dynamic, ongoing crosstalk between these two regulatory systems. Here, we discuss how changes in the recruitment and activation of macrophages contribute to metabolic homeostasis. In particular, we focus our discussion on the pathogenic and protective functions of classically and alternatively activated macrophages, respectively, in experimental models of obesity and metabolic disease.
摘要
代谢和免疫是后生动物的两个基本系统。免疫细胞（如巨噬细胞）存在于代谢组织中，这表明这两个调节系统之间存在动态的、持续的相互作用。在这里，我们讨论了巨噬细胞的募集和激活的变化如何有助于代谢稳态。特别是，我们集中讨论了经典激活和替代激活的巨噬细胞在肥胖和代谢性疾病的实验模型中的分别致病和保护功能。
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