Department of Ocular Biology & Therapeutics, University College London Institute of Ophthalmology, London, United Kingdom.
Stem Cells. 2011 Dec;29(12):1923-32. doi: 10.1002/stem.756.
Limbal epithelial stem cells (LESCs) are a population of stem cells responsible for maintenance and repair of the corneal surface. Injury and disease can result in a deficiency of these stem cells, the vision affecting condition called limbal stem cell deficiency (LSCD) in which the cornea becomes opaque, vascularized, and inflamed. Cultured LESC therapy was first described in 1997;29:19231932-19231932.and LESCs cultured from either patients or donors have been used to successfully treat LSCD. In this review, some of the challenges and controversies associated with cultured LESC therapy will be discussed including alternative stem cell sources.
角膜缘上皮干细胞（LESCs）是一群干细胞，负责维持和修复角膜表面。损伤和疾病可导致这些干细胞缺乏，这种影响视力的情况称为角膜缘干细胞缺乏症（LSCD），其中角膜变得不透明、血管化和炎症。1997 年首次描述了培养的 LESC 治疗；29:19231932-19231932. 并已使用从患者或供体培养的 LESCs 成功治疗 LSCD。在这篇综述中，将讨论与培养的 LESC 治疗相关的一些挑战和争议，包括替代干细胞来源。
