Department of Neonatology, Wilhelmina Children's Hospital/University Medical Centre Utrecht, the Netherlands.
AJNR Am J Neuroradiol. 2012 Jan;33(1):188-94. doi: 10.3174/ajnr.A2723. Epub 2011 Oct 13.
WM injury is associated with different disabilities that children born prematurely may experience during their lives. The aim of this study was to use TBSS to test the hypothesis that WM microstructure at TEA in preterm infants is correlated with cognitive and motor outcome at 2-year corrected age.
Sixty-three preterm infants, born at a mean gestational age of 28.7 weeks, underwent MR imaging and DTI at TEA. Neurodevelopmental performance was assessed by using the BSITD-III. Voxelwise analysis of the DTI data was performed by using TBSS to assess the relationship among FA, AD, and RD at TEA, and cognitive, fine-motor, and gross-motor scores at 2-year corrected age.
Cognitive scores were correlated with FA values in the CC. Fine-motor scores were correlated with FA and RD throughout the WM. Gross-motor scores were associated with RD in the CC, fornix, and internal and external capsule.
WM microstructure in preterm infants at TEA was associated with cognitive, fine-motor, and gross-motor performance at 2-year corrected age. This study suggests that TBSS of DTI data at TEA has the potential to be used as a biomarker for subsequent neurodevelopment.
脑白质（WM）损伤与早产儿在其生命过程中可能经历的不同残疾有关。本研究的目的是使用 TBSS 来检验以下假设，即早产儿 TEA 时的 WM 微观结构与 2 岁校正年龄时的认知和运动结果相关。
63 名胎龄平均为 28.7 周的早产儿在 TEA 时接受了 MRI 和 DTI 检查。使用 BSITD-III 评估神经发育表现。通过 TBSS 对 DTI 数据进行体素分析，以评估 TEA 时 FA、AD 和 RD 与 2 岁校正年龄时认知、精细运动和粗大运动评分之间的关系。
认知评分与 CC 中的 FA 值相关。精细运动评分与 WM 中的 FA 和 RD 均相关。粗大运动评分与 CC、穹窿、内囊和外囊中的 RD 相关。
TEA 时早产儿的 WM 微观结构与 2 岁校正年龄时的认知、精细运动和粗大运动表现相关。本研究表明，TEA 的 DTI 数据的 TBSS 有可能用作后续神经发育的生物标志物。
