Warde M, Gragnani A, Gomes H, Hochman B, Ferreira L M
Division of Plastic Surgery, Federal University of Sao Paulo, São Paulo, Brazil.
Int J STD AIDS. 2011 Oct;22(10):596-9. doi: 10.1258/ijsa.2009.009086.
Life-expectancy increased in patients infected with HIV/AIDS with the advent of highly active antiretroviral therapy (ART). Facial lipoatrophy is a common complication in these patients, eventually leading to stigma, segregation and a negative impact in quality of life (QOL). We measured the impact of the treatment of facial lipoatrophy with polymethyl methacrylate (PMMA) in the QOL of patients with HIV/AIDS by using four questionnaires that address QOL. Forty consecutive patients on ART referred for facial lipoatrophy treatment were enrolled in this study. The first 20 were allocated to the intervention group and were treated with tissue augmentation with PMMA. The other 20 were allocated to the control group, which received treatment only after six months. At baseline, four questionnaires were applied to all patients in both groups and again after six months. The variation in scores within the control group for all domains of all four instruments was significantly better when compared with that within the control group. We detected improvement in the QOL of patients with HIV/AIDS and facial lipoatrophy when they were treated with PMMA.
随着高效抗逆转录病毒疗法（ART）的出现，感染艾滋病毒/艾滋病患者的预期寿命有所增加。面部脂肪萎缩是这些患者的常见并发症，最终会导致耻辱感、隔离以及对生活质量（QOL）产生负面影响。我们通过使用四份涉及生活质量的问卷，来衡量用聚甲基丙烯酸甲酯（PMMA）治疗面部脂肪萎缩对艾滋病毒/艾滋病患者生活质量的影响。本研究纳入了40名连续接受ART治疗且因面部脂肪萎缩前来就诊的患者。前20名被分配到干预组，接受PMMA组织填充治疗。另外20名被分配到对照组，该组在六个月后才接受治疗。在基线时，对两组所有患者应用四份问卷，六个月后再次应用。与对照组相比，所有四项工具所有领域的对照组分数变化明显更好。我们发现，用PMMA治疗艾滋病毒/艾滋病合并面部脂肪萎缩患者时，其生活质量得到了改善。
