Choi Jung Hoon, Won Moo-Ho
Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon, Korea.
Lab Anim Res. 2011 Sep;27(3):181-7. doi: 10.5625/lar.2011.27.3.181. Epub 2011 Sep 30.
The hippocampus plays important roles in the regulation and combination of short and long term memory and spatial navigation with other brain centers. Aging is accompanied by a functional decline of the hippocampus and degenerative disease. Microglia are major immune cells in the central nervous system and response to degenerative changes in the aged brain. In this respect, functional and morphological changes of the hippocampus have been closely related to microglial changes during normal aging with or without disease. Therefore, in this review, we discuss morphological and functional changes of the hippocampus and microglia in the aging brain.
海马体在短期和长期记忆的调节与整合以及与其他脑区的空间导航中发挥着重要作用。衰老伴随着海马体功能衰退和退行性疾病。小胶质细胞是中枢神经系统中的主要免疫细胞，对老年大脑的退行性变化做出反应。在这方面，无论是否患有疾病，在正常衰老过程中，海马体的功能和形态变化都与小胶质细胞的变化密切相关。因此，在本综述中，我们讨论了衰老大脑中海马体和小胶质细胞的形态及功能变化。
