十一酸睾酮用于男性生育控制的临床试验。

Clinical trial with testosterone undecanoate for male fertility control.

作者信息

Nieschlag E, Hoogen H, Bölk M, Schuster H, Wickings E J

出版信息

Contraception. 1978 Dec;18(6):607-14. doi: 10.1016/0010-7824(78)90045-8.

PMID:219988

Abstract

The newly available orally effective testosterone undecanoate (TU) was investigated as a possible means for male fertility control. One of 7 normal volunteers exposed to 80 mg TU three times a day for 10-12 weeks became azoospermic, the remaining showed slightly suppressed or unaffected sperm counts. The insufficient suppression of spermatogenesis in 6 out of 7 subjects may be due to the fact that testosterone levels are only sufficiently high to suppress gonadotropins for some hours after ingestion of the drug.

摘要

新型口服有效的十一酸睾酮（TU）被作为男性生育控制的一种可能手段进行了研究。7名正常志愿者中有1人每天3次服用80毫克TU，持续10 - 12周后出现无精子症，其余志愿者精子计数略有下降或未受影响。7名受试者中有6人精子发生抑制不足，这可能是由于摄入药物后，睾酮水平仅在数小时内足够高以抑制促性腺激素。