Green G M
Department of Physiology, University of Texas Health Science Center, San Antonio 78284-7756.
Pancreas. 1990 Jul;5(4):445-51. doi: 10.1097/00006676-199007000-00012.
The role of gastric juice in the intestine on the pancreatic secretory response to intraduodenal infusion of trypsin inhibitors or to diversion of bile and pancreatic juice from the intestine was studied in conscious rats with pylorus ligation and gastric juice drainage. In absence of gastric juice in the intestine, diversion of bile and pancreatic juice from the intestine stimulated pancreatic secretion, but the incremental protein and fluid secretory responses to diversion of bile and pancreatic juice were increased approximately 2.9-fold and 2.5-fold, respectively, by intraduodenal infusion of HCl (60 microEq/h). Intraduodenal infusion of HCl (240 microEq/h) had no effect on the pancreatic secretory response to infusion of lima bean trypsin inhibitor (20 mg). These results support the hypothesis that the inhibitory effect of atropine on the pancreatic secretory response to diversion of pancreatic juice or bile and pancreatic juice is secondary to inhibition of gastric acid secretion. The lack of effect of HCl on the pancreatic response to trypsin inhibitor contradicts the hypothesis that acid in the intestine is important or necessary for the feedback response to loss of intraluminal protease activity. It is proposed that acid in the intestine augments the pancreatic response to diversion of pancreatic juice or bile and pancreatic juice by reducing intraluminal pH and thereby inactivating residual pancreatic proteases.
在幽门结扎并引流胃液的清醒大鼠中，研究了肠内胃液对胰液分泌反应的作用，该反应是针对十二指肠内注入胰蛋白酶抑制剂或胆汁和胰液从肠道改道的情况。在肠内没有胃液的情况下，胆汁和胰液从肠道改道会刺激胰腺分泌，但十二指肠内注入盐酸（60微当量/小时）可使胆汁和胰液改道后蛋白质和液体分泌的增量反应分别增加约2.9倍和2.5倍。十二指肠内注入盐酸（240微当量/小时）对注入利马豆胰蛋白酶抑制剂（20毫克）后的胰腺分泌反应没有影响。这些结果支持了以下假设：阿托品对胰液或胆汁和胰液改道后的胰腺分泌反应的抑制作用继发于胃酸分泌的抑制。盐酸对胰腺对胰蛋白酶抑制剂反应缺乏影响，这与肠内酸对腔内蛋白酶活性丧失的反馈反应很重要或必不可少的假设相矛盾。有人提出，肠内酸通过降低腔内pH值从而使残留的胰腺蛋白酶失活，增强了胰腺对胰液或胆汁和胰液改道的反应。
