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犬躯干皮肤芽生菌病的诊断与治疗

Diagnosis and treatment of truncal cutaneous pythiosis in a dog.

作者信息

Thieman Kelley M, Kirkby Kristin A, Flynn-Lurie Alison, Grooters Amy M, Bacon Nicholas J

机构信息

Department of Small Animal Clinical Sciences, Veterinary Medical Center, College of Veterinary Medicine, University of Florida, Gainesville, 32611, USA.

出版信息

J Am Vet Med Assoc. 2011 Nov 1;239(9):1232-5. doi: 10.2460/javma.239.9.1232.

Abstract

CASE DESCRIPTION

A 4-year-old spayed female Boxer was evaluated for a cutaneous mass located on the dorsum. The mass had been present for 6 weeks and was increasing in size.

CLINICAL FINDINGS

A mass of approximately 10 cm in diameter was detected on the dorsum cranial to the right ilial wing. Histologic examination of a tissue sample from the mass led to the diagnosis of cutaneous pythiosis. Computed tomography of the abdomen and the mass were performed and revealed a contrast-enhancing soft tissue mass of the dorsum and enlarged intra-abdominal lymph nodes.

TREATMENT AND OUTCOME

The dog underwent surgical excision of the cutaneous mass, including 5-cm skin margins and deep margins of 2 fascial planes. The mass was completely excised on the basis of results of histologic examination of surgical margins. The dog received itraconazole and terbinafine by mouth for 3 months following surgery. Recheck examination at 20 months postoperatively showed no signs of recurrence of pythiosis at the surgical site.

CLINICAL RELEVANCE

Aggressive surgical excision in combination with medical treatment resulted in a favorable long-term (> 1 year) outcome in this dog. Thorough workup including diagnostic imaging and lymph node evaluation is recommended. If surgery is to be performed, skin margins of 5 cm and deep margins of 2 fascial planes are recommended.

摘要

病例描述

一只4岁已绝育的雌性拳师犬因背部出现皮肤肿物而接受评估。该肿物已存在6周,且在不断增大。

临床检查结果

在右髂骨翼上方的背部检测到一个直径约10厘米的肿物。对肿物组织样本进行组织学检查后诊断为皮肤芽生菌病。对腹部和肿物进行了计算机断层扫描,结果显示背部有一个强化的软组织肿物以及腹腔内淋巴结肿大。

治疗与结果

这只犬接受了皮肤肿物的手术切除,包括5厘米的皮肤切缘和2个筋膜平面的深部切缘。根据手术切缘的组织学检查结果,肿物被完全切除。术后这只犬口服伊曲康唑和特比萘芬3个月。术后20个月的复查显示手术部位没有皮肤芽生菌病复发的迹象。

临床意义

在这只犬中,积极的手术切除联合药物治疗取得了良好的长期(>1年)效果。建议进行包括诊断性影像学检查和淋巴结评估在内的全面检查。如果要进行手术,建议皮肤切缘为5厘米,深部切缘为2个筋膜平面。

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