Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina, USA.
Med Mycol. 2011 Jul;49(5):539-42. doi: 10.3109/13693786.2010.543705. Epub 2010 Dec 21.
Medical therapy for pythiosis is hampered by a lack of efficacious drugs. The present report describes a case of canine gastrointestinal pythiosis in which lesions were resolved through the administration of itraconazole, terbinafine, and the agricultural fungicide mefenoxam. No substantial adverse effects occurred in association with administration of the latter compound. Additional studies are needed to evaluate the pharmacokinetics of mefenoxam and to further assess its tolerability and potential efficacy for the treatment of pythiosis in dogs.
医学治疗锥体虫病受到缺乏有效药物的阻碍。本报告描述了一例犬胃肠道锥体虫病病例，通过给予伊曲康唑、特比萘芬和农用杀菌剂甲霜灵，病变得到解决。与后者化合物给药相关，未发生实质性不良反应。需要进一步的研究来评估甲霜灵的药代动力学，并进一步评估其在犬锥体虫病治疗中的耐受性和潜在疗效。
