The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, Scotland, UK.
Semin Cell Dev Biol. 2011 Dec;22(9):935-45. doi: 10.1016/j.semcdb.2011.09.023. Epub 2011 Oct 6.
Kinesin motor proteins are ubiquitously involved in multiple fundamental cellular processes, coordinating transport and mediating changes to cellular architecture. Thus, specific small molecule kinesin inhibitors can shed new light on the functions of kinesins and the dynamic roles in which they participate. Here we review the range of known inhibitors, their key characteristics, and specificity, and discuss their potential suitability for chemical genetics as starting points to further investigate complex kinesin-mediated processes.
驱动蛋白马达蛋白广泛参与多种基本的细胞过程，协调运输并介导细胞结构的变化。因此，特定的小分子驱动蛋白抑制剂可以揭示驱动蛋白的功能以及它们参与的动态作用。在这里，我们回顾了已知的抑制剂的范围、它们的关键特性和特异性，并讨论了它们作为进一步研究复杂驱动蛋白介导过程的起点，用于化学遗传学的潜在适用性。
