Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore.
Int J Pharm. 2012 Jan 17;422(1-2):17-23. doi: 10.1016/j.ijpharm.2011.10.015. Epub 2011 Oct 6.
Cone mill was well studied for milling of wet agglomerates. This study evaluated the effects of various process parameters of cone milling roller compacted flakes on the granules produced. Impeller sidearm shapes, screen surface profiles and impeller speeds were studied. Impeller speed was found to play a major role in determining the granule attributes. Besides this, median size, size distribution and percent fines of a milled granule population were mainly determined by the size reduction mechanisms of different impellers and screens. Pre-breaking followed by shearing and slicing of flakes inside the milling chamber was primarily responsible for determining the size, size distribution and percent fines of milled granules. The pre-breaking action could be achieved using teethed round sidearm impeller and lowered the need for screen-based size reduction, thus generating less fines. The shearing and slicing of flakes due to the raised impaction edges of the grater screen also helped to minimize the production of fines. Therefore, the lowest percentage of fines was observed when the teethed round sidearm impeller was used with a grater screen. The results indicated that fines can be reduced considerably with the judicious selection of a suitable impeller and screen combination in the cone mill.
锥形磨在湿式团聚体的粉碎方面已有广泛研究。本研究评估了锥形磨辊压片过程中各种工艺参数对所制得颗粒的影响。研究了叶轮侧臂形状、筛网表面轮廓和叶轮转速。研究发现，叶轮转速在确定颗粒特性方面起着主要作用。除此之外，中位粒径、粒径分布和细粉百分率主要取决于不同叶轮和筛网的粉碎机制。在粉碎室内，薄片首先被预破碎，然后被剪切和切片，这主要决定了粉碎颗粒的大小、粒径分布和细粉百分率。预破碎作用可以通过带齿的圆形侧臂叶轮来实现，从而降低了对筛网尺寸减小的需求，从而减少了细粉的生成。由于格栅筛的凸起冲击边缘，薄片的剪切和切片也有助于最大限度地减少细粉的产生。因此，当使用带齿的圆形侧臂叶轮和格栅筛时，观察到细粉的百分率最低。结果表明，在锥形磨中，通过明智地选择合适的叶轮和筛网组合，可以大大减少细粉的产生。
