Shen Rong, Shuai Jian-Wei
Department of Computer Science, Sichuan University of Arts and Science, Dazhou, China.
Sheng Li Xue Bao. 2011 Oct 25;63(5):442-52.
Cytosolic Ca(2+) ions play an important role in the regulation of numerous aspects of cellular activity in virtually all cell types. There is a complex interaction between the neuronal electrical signals on plasma membrane and the chemical signals of intracellular calcium. Each neuron can be considered as a binary membrane system with plasma membrane and endoplasmic reticulum membrane, and the neuronal endoplasmic reticulum can be regarded as a neuron-within-a-neuron. This review explores the simulation modeling of neuronal dynamics mutually coupled with the intracellular calcium signaling released from endoplasmic reticulum through the inositol 1,4,5-trisphosphate receptor calcium channels. We show that a current trend is to include the intracellular calcium dynamics into the neuronal models, and the frontier of this research is now shifting to spatial neuronal models with diffusing intracellular calcium. It is expected that more important results will be obtained with the neuronal models incorporating the intracellular calcium dynamics, especially the spatial models considering the calcium diffusion both in soma and dendritic branches.
胞质钙离子在几乎所有细胞类型的细胞活动诸多方面的调节中发挥着重要作用。质膜上的神经元电信号与细胞内钙的化学信号之间存在复杂的相互作用。每个神经元可被视为具有质膜和内质网膜的二元膜系统，并且神经元内质网可被视为一个“神经元中的神经元”。本综述探讨了通过肌醇1,4,5 - 三磷酸受体钙通道从内质网释放的细胞内钙信号与神经元动力学相互耦合的模拟建模。我们表明，当前的一个趋势是将细胞内钙动力学纳入神经元模型，并且该研究的前沿现在正转向具有扩散性细胞内钙的空间神经元模型。预计在纳入细胞内钙动力学的神经元模型中，尤其是考虑钙在胞体和树突分支中扩散的空间模型，将获得更重要的结果。
