Lavrentovich Maxim, Hemkin Sheryl
Department of Chemistry, Kenyon College, Gambier, OH 43022, USA.
J Theor Biol. 2008 Apr 21;251(4):553-60. doi: 10.1016/j.jtbi.2007.12.011. Epub 2008 Feb 14.
Astrocytes exhibit oscillations and waves of Ca2+ ions within their cytosol and it appears that this behavior helps facilitate the astrocyte's interaction with its environment, including its neighboring neurons. Often changes in the oscillatory behavior are initiated by an external stimulus such as glutamate, recently however, it has been observed that oscillations are also initiated spontaneously. We propose here a mathematical model of how spontaneous Ca2+ oscillations arise in astrocytes. This model uses the calcium-induced calcium release and inositol cross-coupling mechanisms coupled with a receptor-independent method for producing inositol (1,4,5)-trisphosphate as the heart of the model. By computationally mimicking experimental constraints we have found that this model provides results that are qualitatively similar to experiment.
星形胶质细胞的胞质溶胶内会出现钙离子振荡和波动，这种行为似乎有助于促进星形胶质细胞与其周围环境（包括相邻神经元）的相互作用。振荡行为的变化通常由谷氨酸等外部刺激引发，然而最近观察到振荡也会自发产生。我们在此提出一个关于星形胶质细胞中自发钙离子振荡如何产生的数学模型。该模型采用钙诱导钙释放和肌醇交叉偶联机制，并结合一种不依赖受体产生肌醇（1,4,5）-三磷酸的方法作为模型核心。通过计算模拟实验条件，我们发现该模型得出的结果在性质上与实验相似。
