Department of Agriculture, Fisheries, and Food, Coosan, Athlone, Ireland.
Vet Pathol. 2012 May;49(3):462-9. doi: 10.1177/0300985811424732. Epub 2011 Oct 15.
Six ovine fetal brains were harvested 33 to 35 days postchallenge from 5 ewes, each of which was given 3000 Toxoplasma gondii oocysts on day 90 of pregnancy. Histopathologic examination of transverse sections taken at 13 levels in the fetal brains revealed the presence of toxoplasmosis-related lesions in all 6 brains. However, lesions were not randomly distributed (P = .007); they were most numerous at the level of the optic tract, the rostral margin of the pons, and 4 mm caudal to the ansate sulcus and were absent in all sections at the level of the caudal cerebellum. Lesion distribution may be due to hemodynamic factors, differences in the expression of endothelial surface receptor molecules at the level of the blood-brain barrier, or the presence of localized permissive/inhibitory factors within the brain. The results have implications for the selection of areas of brain from aborted ovine fetuses to be examined histopathologically for laboratory diagnosis.
从 5 只怀孕 90 天的母羊中收获了 33 至 35 天龄的 6 个胎儿大脑，每只母羊在怀孕第 90 天接受了 3000 个刚地弓形虫卵囊。对胎儿大脑中 13 个水平的横切进行组织病理学检查，发现 6 个大脑中均存在与弓形虫病相关的病变。然而，病变并非随机分布（P=.007）；它们在视束、脑桥的前缘和ansate 沟后 4 毫米处最为常见，在小脑尾部的所有切片中均不存在病变。病变分布可能与血流动力学因素、血脑屏障内皮表面受体分子表达的差异或脑内局部许可/抑制因素有关。这些结果对选择流产胎儿的脑区进行组织病理学检查以进行实验室诊断具有重要意义。
