Thompson Nia, Nazir Niaman, Cox Lisa Sanderson, Faseru Babalola, Goggin Kathy, Ahluwalia Jasjit S, Nollen Nicole L
University of Kansas School of Medicine, Department of Preventive Medicine and Public Health, Kansas City, KS, USA.
Patient Prefer Adherence. 2011;5:475-82. doi: 10.2147/PPA.S24023. Epub 2011 Sep 28.
Despite consistent evidence linking smoking cessation pharmacotherapy adherence to better outcomes, knowledge about objective adherence measures is lacking and little attention is given to monitoring pharmacotherapy use in smoking cessation clinical trials.
To examine unannounced telephone pill counts as a method for assessing adherence to smoking cessation pharmacotherapy.
Secondary data analysis of a randomized pilot study.
46 moderate-to-heavy (>10 cigarettes per day) African-American smokers.
Smokers received 1 month of varenicline (Pfizer Global Pharmaceuticals, New York, NY) in a pill box at baseline. Unannounced pill counts were completed by telephone 4 days prior to an in-person pill count conducted at Month 1. At both counts, each compartment of the pill box was opened and the number of remaining pills was recorded.
Participants were a mean age of 48 years (SD = 13), predominately female (59%), low income (60% < $1800 monthly family income), and smoked an average of 17 (SD = 7) cigarettes per day. A high degree of concordance was observed between the number of pills counted by phone and in-person (r(s) = 0.94, P < 0.001). Participants with discordant counts (n = 7) had lower varenicline adherence (mean [SD] = 77% [18%] vs 95% [9%], P < 0.0005), but reported better medication adherence in the past (1.0 [0.8] vs 2.8 [1.0], P < 0.0004) than participants with matching phone and in-person counts (n = 39).
Unannounced telephone pill counts appear to be a reliable and practical method for measuring adherence to smoking cessation pharmacotherapy.
尽管有一致的证据表明戒烟药物治疗的依从性与更好的治疗效果相关，但关于客观依从性测量方法的知识仍然匮乏，并且在戒烟临床试验中很少关注对药物治疗使用情况的监测。
检验不预先通知的电话清点药片作为评估戒烟药物治疗依从性的一种方法。
一项随机试点研究的二次数据分析。
46名中度至重度（每天吸烟超过10支）的非裔美国吸烟者。
吸烟者在基线时在药盒中领取了1个月的伐尼克兰（辉瑞全球制药公司，纽约，纽约州）。在第1个月进行面对面清点药片的4天前，通过电话完成不预先通知的药片清点。在两次清点时，药盒的每个隔层都被打开，并记录剩余药片的数量。
参与者的平均年龄为48岁（标准差=13），主要为女性（59%），低收入（60%家庭月收入<1800美元），平均每天吸烟17支（标准差=7）。通过电话清点和面对面清点的药片数量之间观察到高度一致性（r(s)=0.94，P<0.001）。清点结果不一致的参与者（n=7）的伐尼克兰依从性较低（平均[标准差]=77%[18%]对95%[9%]，P<0.0005），但与电话清点和面对面清点结果匹配的参与者（n=39）相比，他们过去报告的药物依从性更好（1.0[0.8]对2.8[1.0]，P<0.0004）。
不预先通知的电话清点药片似乎是一种可靠且实用的测量戒烟药物治疗依从性的方法。
