Kalichman Seth C, Amaral Christina, Swetsze Connie, Eaton Lisa, Kalichman Moira O, Cherry Chauncey, Detorio Mervi, Caliendo Angela M, Schinazi Raymond F
Department of Psychology, University of Connecticut, Storrs, Connecticut 06269, USA.
HIV Clin Trials. 2010 Nov-Dec;11(6):325-31. doi: 10.1310/hct1106-325.
Unannounced home-based pill counts conducted in person or on the telephone are reliable and valid for monitoring medication adherence. However, expecting to have one's pills counted, organizing medications for pill counts, and increased attention from the person conducting the pill counts may have reactive effects and inadvertently improve adherence. The current study determined whether monthly unannounced pill counts conducted by telephone influence adherence over time.
Two prospective cohorts, one drawn from a social support condition in a behavioral intervention trial (n=186) and the other an observational study (n=187), were followed for 12 months and 8 months, respectively. Medication adherence was monitored using monthly unannounced pill counts conducted by telephone. In addition, blood plasma viral load was collected at the final pill count for the observational cohort.
Analyses did not indicate increases in medication adherence over time for antiretroviral or psychiatric medications among men, women, people with detectable and undetectable viral loads, and various medication regimens.
Unannounced pill counts conducted by telephone do not demonstrate reactivity effects and remain a viable, unobtrusive, objective method of monitoring medication adherence.
亲自上门或通过电话进行的不预先通知的家庭药丸计数，对于监测药物依从性是可靠且有效的。然而，预期自己的药丸会被计数、为药丸计数整理药物以及进行药丸计数的人员增加关注，可能会产生反应性影响，并无意中提高依从性。当前研究确定通过电话每月进行的不预先通知的药丸计数是否会随着时间的推移影响依从性。
两个前瞻性队列，一个来自行为干预试验中的社会支持条件组（n = 186），另一个是观察性研究（n = 187），分别随访12个月和8个月。使用通过电话每月进行的不预先通知的药丸计数来监测药物依从性。此外，在观察性队列的最后一次药丸计数时收集血浆病毒载量。
分析未表明男性、女性、病毒载量可检测和不可检测的人群以及各种药物治疗方案中，抗逆转录病毒药物或精神药物的药物依从性随时间增加。
通过电话进行的不预先通知的药丸计数未显示出反应性影响，仍然是一种可行、不引人注意、客观的监测药物依从性的方法。
