在未成熟大脑中寻找癫痫生物标志物：目标、挑战与策略。
In search of epilepsy biomarkers in the immature brain: goals, challenges and strategies.
机构信息
Saul R Korey Department of Neurology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Kennedy Center, Room 306, Bronx, NY 10461, USA.
出版信息
Biomark Med. 2011 Oct;5(5):615-28. doi: 10.2217/bmm.11.71.
Abstract
Epilepsy and seizures are very common in the early years of life and are often associated with significant morbidity and mortality. Identification of biomarkers for the early detection of epileptogenicity, epileptogenesis, comorbidities, disease progression and treatment implementation will be very important in implementing more effective therapies. This article summarizes the current needs in the search for new early life epilepsy-related biomarkers and discusses the candidate biomarkers that are under investigation, as well as the challenges associated with the identification and validation of these biomarkers.
摘要
癫痫和发作在生命早期非常常见，通常与显著的发病率和死亡率相关。识别生物标志物对于早期发现致痫性、癫痫发生、合并症、疾病进展和治疗实施将非常重要，有助于实施更有效的治疗方法。本文总结了目前在寻找新的与生命早期癫痫相关的生物标志物方面的需求，并讨论了正在研究的候选生物标志物，以及鉴定和验证这些生物标志物所面临的挑战。
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本文引用的文献
1
Brain inflammation as a biomarker in epilepsy.
Biomark Med. 2011 Oct;5(5):607-14. doi: 10.2217/bmm.11.61.
2
Prospects for imaging-related biomarkers of human epileptogenesis: a critical review.
Biomark Med. 2011 Oct;5(5):599-606. doi: 10.2217/bmm.11.66.
3
Hippocampal MRI and other structural biomarkers: experimental approach to epileptogenesis.
Biomark Med. 2011 Oct;5(5):585-97. doi: 10.2217/bmm.11.65.
4
α-[¹¹C]-methyl-L-tryptophan PET for tracer localization of epileptogenic brain regions: clinical studies.
Biomark Med. 2011 Oct;5(5):577-84. doi: 10.2217/bmm.11.68.
5
α-methyl-L-tryptophan: mechanisms for tracer localization of epileptogenic brain regions.
Biomark Med. 2011 Oct;5(5):567-75. doi: 10.2217/bmm.11.73.
6
High-frequency oscillations and other electrophysiological biomarkers of epilepsy: clinical studies.
Biomark Med. 2011 Oct;5(5):557-66. doi: 10.2217/bmm.11.74.
7
High-frequency oscillations and other electrophysiological biomarkers of epilepsy: underlying mechanisms.
Biomark Med. 2011 Oct;5(5):545-56. doi: 10.2217/bmm.11.72.
8
A pulse rapamycin therapy for infantile spasms and associated cognitive decline.
Neurobiol Dis. 2011 Aug;43(2):322-9. doi: 10.1016/j.nbd.2011.03.021. Epub 2011 Apr 12.
9
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Epilepsia. 2011 Jan;52(1):53-62. doi: 10.1111/j.1528-1167.2010.02887.x. Epub 2011 Jan 4.
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Long-term mortality in childhood-onset epilepsy.
N Engl J Med. 2010 Dec 23;363(26):2522-9. doi: 10.1056/NEJMoa0911610.
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