微波辅助 Pd/Cu 催化嘌呤和相关唑类的 C-8 直接烯丙基化反应：一种构建 6,8,9-三取代嘌呤的替代方法。
Microwave-assisted Pd/Cu-catalyzed C-8 direct alkenylation of purines and related azoles: an alternative access to 6,8,9-trisubstituted purines.
机构信息
Univ Paris-Sud, Orsay, F-91405, France.
出版信息
J Org Chem. 2011 Nov 18;76(22):9542-7. doi: 10.1021/jo201893h. Epub 2011 Oct 26.
PMID:22004273
Abstract
An efficient microwave-assisted palladium/copper comediated C-8 direct alkenylation of purines with styryl bromides has been developed. The method is regioselective, functional group tolerant, rapid, and compatible with other related azoles. Combined with subsequent nucleophilic substitution, it provides an easy access to new 6,8,9-trisubstituted purines.
摘要
一种高效的微波辅助钯/铜协同 C-8 直接烯丙基化嘌呤与苯乙烯基溴的方法已经被开发出来。该方法具有区域选择性、官能团耐受性、快速和与其他相关唑类化合物兼容的特点。结合后续的亲核取代反应，它为新型 6,8,9-三取代嘌呤提供了一种简便的合成途径。
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