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青少年共病物质滥用和自杀倾向的治疗:一项随机试验。

Treatment of co-occurring substance abuse and suicidality among adolescents: a randomized trial.

机构信息

Department of Psychology, George Mason University, Fairfax, VA 22030, USA.

出版信息

J Consult Clin Psychol. 2011 Dec;79(6):728-39. doi: 10.1037/a0026074. Epub 2011 Oct 17.

Abstract

OBJECTIVE

This study tested a cognitive-behavioral treatment protocol for adolescents with a co-occurring alcohol or other drug use disorder (AOD) and suicidality in a randomized clinical trial.

METHOD

Forty adolescents (Mage = 15 years; 68% female, 89% White) and their families recruited from an inpatient psychiatric hospital were randomly assigned to an integrated outpatient cognitive-behavioral intervention for co-occurring AOD and suicidality (I-CBT) or enhanced treatment as usual (E-TAU). Primary measures include the Schedule for Affective Disorders and Schizophrenia for School-Age Children, Suicide Ideation Questionnaire, Columbia Impairment Scale, Timeline Followback, Rutgers Alcohol Problem Index, and Rutgers Marijuana Problem Index. Assessments were completed at pretreatment as well as 3, 6, 12, and 18 months postenrollment.

RESULTS

In intent-to-treat analyses, I-CBT was associated with significantly fewer heavy drinking days and days of marijuana use relative to E-TAU but not with fewer drinking days. Those randomized to I-CBT in comparison to E-TAU also reported significantly less global impairment as well as fewer suicide attempts, inpatient psychiatric hospitalizations, emergency department visits, and arrests. Adolescents across groups showed equivalent reductions in suicidal ideation.

CONCLUSIONS

I-CBT for adolescents with co-occurring AOD and suicidality is associated with significant improvement in both substance use and suicidal behavior, as well as markedly decreased use of additional health services including inpatient psychiatric hospitalizations and emergency department visits. Further testing of integrated protocols for adolescent AOD and suicidality with larger and more diverse samples is warranted.

摘要

目的

本研究在一项随机临床试验中测试了一种针对同时患有酒精或其他药物使用障碍(AOD)和自杀意念的青少年的认知行为治疗方案。

方法

40 名青少年(平均年龄=15 岁;68%为女性,89%为白人)及其家庭从一家住院精神病院招募,随机分配到同时治疗 AOD 和自杀意念的综合门诊认知行为干预(I-CBT)或增强的常规治疗(E-TAU)。主要措施包括儿童青少年情感障碍和精神分裂症时间表、自杀意念问卷、哥伦比亚损伤量表、时间线回溯、罗格斯酒精问题指数和罗格斯大麻问题指数。评估在治疗前以及治疗后 3、6、12 和 18 个月进行。

结果

意向性治疗分析显示,与 E-TAU 相比,I-CBT 与饮酒天数和大麻使用天数的显著减少相关,但与饮酒天数的减少无关。与 E-TAU 相比,随机分配到 I-CBT 的患者报告的总体损伤以及自杀企图、住院精神病院治疗、急诊就诊和逮捕次数也显著减少。所有组别的青少年的自杀意念均有同等程度的减少。

结论

针对同时患有 AOD 和自杀意念的青少年的 I-CBT 与物质使用和自杀行为的显著改善相关,以及包括住院精神病院治疗和急诊就诊在内的额外卫生服务的使用显著减少。需要进一步测试针对青少年 AOD 和自杀意念的综合方案,样本量更大,更加多样化。

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