Department of Neurology, Zonguldak Karaelmas University Medical Faculty, Zonguldak, Turkey.
J Sleep Res. 2012 Jun;21(3):281-8. doi: 10.1111/j.1365-2869.2011.00976.x. Epub 2011 Oct 17.
Behçet's disease, a systemic vasculitis, can cause varying degrees of activity limitation, fatigue and quality of life impairment. To date, there have been no studies regarding sleep disturbance and its relationship with fatigue and life quality in Behçet's disease. We aimed to evaluate sleep disorders and polysomnographic parameters, and to determine their relationship with fatigue and quality of life in Behçet's disease. Fifty-one patients with Behçet's disease without any neurological involvement were interviewed regarding sleep disorders. Twenty-one subjects with no sleep complaints were included as the control group. Sleep-related complaints were evaluated in a face-to-face interview. Sleep quality, excessive daytime sleepiness, fatigue, depression, anxiety, disease activity/severity, and quality of life questionnaires and an overnight polysomnography were performed. Prevalences of restless legs syndrome (35.3%) and obstructive sleep apnea syndrome with/without other sleep disorders (32.5%) were higher than in the control group and the general population. Fatigue was higher in patients with restless legs syndrome and obstructive sleep apnea syndrome, and in those with lower minimum oxygen saturation; hence, only patients with restless legs syndrome had quality of life impairment. Sleep efficiency index and sleep continuity index were lower, and wake after sleep onset, respiratory disturbance index and apnea-hypopnea index were higher than in controls (P < 0.01). Neither sleep disorders nor polysomnographic parameters were related to disease activity and severity. In conclusion, it is important to question sleep disorder followed by a polysomnography, if necessary, in order to improve quality of life and fatigue in Behçet's disease.
白塞病是一种系统性血管炎，可导致不同程度的活动受限、疲劳和生活质量受损。迄今为止，尚无关于白塞病睡眠障碍及其与疲劳和生活质量关系的研究。我们旨在评估白塞病患者的睡眠障碍和多导睡眠图参数，并确定其与疲劳和生活质量的关系。对 51 例无神经系统受累的白塞病患者进行了睡眠障碍访谈。21 例无睡眠主诉的受试者作为对照组纳入。通过面对面访谈评估与睡眠相关的抱怨。进行睡眠质量、日间嗜睡、疲劳、抑郁、焦虑、疾病活动/严重程度和生活质量问卷评估以及整夜多导睡眠图检查。不宁腿综合征（35.3%）和阻塞性睡眠呼吸暂停综合征伴/不伴其他睡眠障碍（32.5%）的患病率高于对照组和普通人群。不宁腿综合征和阻塞性睡眠呼吸暂停综合征患者的疲劳程度更高，最低氧饱和度更低，因此只有不宁腿综合征患者的生活质量受损。睡眠效率指数和睡眠连续性指数较低，而入睡后觉醒、呼吸障碍指数和呼吸暂停低通气指数较高（P < 0.01）。睡眠障碍和多导睡眠图参数均与疾病活动和严重程度无关。总之，如果有必要，对白塞病患者进行睡眠障碍和多导睡眠图检查以改善生活质量和疲劳非常重要。
