Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, CA, USA.
Department of Dermatology, Hospital del Mar, UAB, Barcelona, Spain.
Int J Dermatol. 2011 Nov;50(11):1421-1427. doi: 10.1111/j.1365-4632.2011.04970.x.
Contact dermatitises, including allergic contact dermatitis and irritant contact dermatitis, are among the most common skin disorders in humans. Chinese herbal medicines (CHM) have been used in treating contact dermatitises for centuries. Systemic administration of CHM, including ingredients in huangdang mixture containing Chinese angelica, radix Paeonlae rubra, cat nut, and phelloden dron, rhizoma alismatis, rhizoma smilacis glabrae, and rhizome of swordlike, improves allergic contact dermatitis induced by l-fluoro-2,4-dinitrobenzene. Whether topical applications of these herbal extracts display preventive and/or therapeutic effects on contact dermatitis, thereby avoiding the potential side effects of systemic CHM, remains largely unknown.
To determine whether this topical CHM extract exerts preventive and/or therapeutic effects, we assessed its efficacy in both allergic contact dermatitis and irritant contact dermatitis murine models.
Allergic contact dermatitis and irritant contact dermatitis murine models were established by topical oxazolone and a phorbol ester (12-O-tetradecanoylphorbol-13-acetate; TPA), respectively. Ear thickness was assessed in both dermatitis models.
Our results demonstrate that this topical CHM extract exhibits both therapeutic and preventive effects in acute irritant contact dermatitis but no demonstrable efficacy in murine allergic contact dermatitis.
These results suggest that this topical CHM extract could provide an alternative regimen for the prevention and treatment of irritant contact dermatitis.
接触性皮炎，包括过敏性接触性皮炎和刺激性接触性皮炎，是人类最常见的皮肤疾病之一。中药（CHM）已被用于治疗接触性皮炎数百年。CHM 的系统给药，包括含当归、赤芍、猫爪草、泽泻、山药、菝葜和剑叶的黄党合剂的成分，可改善 l-氟-2,4-二硝基苯引起的过敏性接触性皮炎。这些草药提取物的局部应用是否对接触性皮炎具有预防和/或治疗作用，从而避免 CHM 的潜在全身副作用，在很大程度上仍不清楚。
为了确定这种局部 CHM 提取物是否具有预防和/或治疗作用，我们评估了它在过敏性接触性皮炎和刺激性接触性皮炎小鼠模型中的疗效。
通过局部使用恶唑酮和一种佛波酯（12-O-十四烷酰佛波醇-13-乙酸酯；TPA）分别建立过敏性接触性皮炎和刺激性接触性皮炎小鼠模型。在两种皮炎模型中评估耳厚度。
我们的结果表明，这种局部 CHM 提取物在急性刺激性接触性皮炎中具有治疗和预防作用，但在小鼠过敏性接触性皮炎中没有明显疗效。
这些结果表明，这种局部 CHM 提取物可为预防和治疗刺激性接触性皮炎提供替代方案。
