URGV Plant Genomics, INRA-CNRS-University of Evry, Evry, France.
Plant Signal Behav. 2011 Jul;6(7):1030-3. doi: 10.4161/psb.6.7.15580.
More than 100,000 publications demonstrate that AGC kinases are important regulators of growth, metabolism, proliferation, cell divison, survival and apoptosis in mammalian systems. Mutation and/or dysregulation of these kinases contribute to the pathogenesis of many human diseases, including cancer and diabetes. Although AGC kinases are also present in plants, little is known about their functions. We demonstrated that the AGC kinase OXIDATIVE SIGNAL-INDUCIBLE 1 (OXI1/AGC2-1) regulate important developmental processes and defense responses in plants. The summary of recent progress also demonstrates that we are only beginning to understand the role of this kinase pathway in plants.
超过 10 万篇文献证明，AGC 激酶是哺乳动物系统中生长、代谢、增殖、细胞分裂、存活和凋亡的重要调节剂。这些激酶的突变和/或失调导致许多人类疾病的发病机制，包括癌症和糖尿病。尽管 AGC 激酶也存在于植物中，但对其功能知之甚少。我们证明，AGC 激酶 OXIDATIVE SIGNAL-INDUCIBLE 1（OXI1/AGC2-1）调节植物中的重要发育过程和防御反应。最近进展的总结也表明，我们才刚刚开始了解该激酶途径在植物中的作用。
