Department of Internal Medicine, Zafra County Hospital, Zafra, Spain.
J Stroke Cerebrovasc Dis. 2013 May;22(4):297-303. doi: 10.1016/j.jstrokecerebrovasdis.2011.09.009. Epub 2011 Oct 17.
Mean platelet volume (MPV) could be a predictor of prognosis after ischemic stroke. Our aim is to investigate the association of MPV with a greater mortality and morbidity (defined as readmissions) after 1 year of follow-up in patients with acute stroke, and with a poor functional outcome in these patients.
Patients with ischemic stroke (N = 379) were recruited and assessed for an average of 46.27 weeks. MPV was measured at admission. The sample was divided in thirds according with the tertiles of distribution of MPV. Univariate and multivariate analysis were performed.
The median (interquartile range) of MPV by third was 10 (0.7), 11(0.4), and 12 (0.8) fentoliters. Patients within highest third had a significant higher risk of either death or readmission (odds ratio 1.3; 95% confidence interval 1.00-1.7; P < .048) compared with patients within the lowest third. Functional outcome, defined as a modified Rankin Scale score of 3 to 6, was significantly higher (P < .0004) by greater third of MPV.
MPV may be an easily available predictor for the prognosis in patients with acute ischemic stroke.
平均血小板体积（MPV）可能是缺血性中风后预后的预测指标。我们的目的是探讨 MPV 与急性中风患者 1 年后死亡率和发病率（定义为再入院）增加的相关性，以及与这些患者不良功能结局的相关性。
招募了 379 名缺血性中风患者并进行了平均 46.27 周的评估。入院时测量了 MPV。根据 MPV 的分布三分位数将样本分为三部分。进行了单变量和多变量分析。
MPV 的中位数（四分位数间距）按三分位数分别为 10（0.7）、11（0.4）和 12（0.8）飞升。与最低三分位数的患者相比，处于最高三分位数的患者有更高的死亡或再入院风险（优势比 1.3；95%置信区间 1.00-1.7；P<.048）。功能结局定义为改良 Rankin 量表评分 3-6 分，MPV 较大的三分位数显著更高（P<.0004）。
MPV 可能是急性缺血性中风患者预后的一个易于获得的预测指标。
