Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
Nutr Neurosci. 2011 Sep;14(5):195-201. doi: 10.1179/1476830511Y.0000000011.
There are no human studies assessing the effect of nutritional interventions on plasma brain-derived neurotrophic factor (BDNF) concentrations. The aim of this study was to assess the role of a nutritional intervention based on a Mediterranean diet (MeDiet) on plasma BDNF levels.
PREvención con Dieta MEDiterránea (PREDIMED) is a randomized clinical trial designed to assess the effect of a Mediterranean diet (MeDiet) on the primary prevention of cardiovascular disease. For this analysis, 243 participants from the Navarra centre were randomly selected. Participants were assigned to one of three dietary interventions: control (low-fat) diet, MeDiet supplemented with virgin olive oil (MeDiet+VOO), or MeDiet supplemented with nuts (MeDiet+Nuts). Plasma BDNF levels were measured after 3 years of intervention. Multivariate-adjusted means of BDNF for each intervention were compared using generalized linear models. Logistic regression models were fit to assess the association between the dietary intervention and the likelihood to have low plasma BDNF values (<13 µg/ml, 10th percentile). Analyses were repeated after stratifying the sample according to baseline prevalence of different diseases.
Higher but non-significant plasma BDNF levels were observed for participants assigned to both MeDiets. Participants assigned to MeDiet+Nuts showed a significant lower risk (odds ratios (OR)=0.22; 95% confidence intervals (CI)=0.05-0.90) of low plasma BDNF values (<13 µg/ml) as compared to the control group. Among participants with prevalent depression at baseline, significantly higher BDNF levels were found for those assigned to the MeDiet+Nuts.
Adherence to a MeDiet was associated to an improvement in plasma BDNF concentrations in individuals with depression.
目前尚无研究评估营养干预对血浆脑源性神经营养因子（BDNF）浓度的影响。本研究旨在评估基于地中海饮食（MeDiet）的营养干预对血浆 BDNF 水平的作用。
PREvención con Dieta MEDiterránea（PREDIMED）是一项随机临床试验，旨在评估地中海饮食（MeDiet）对心血管疾病一级预防的影响。本分析中，随机选择了纳瓦拉中心的 243 名参与者。参与者被分配到以下三种饮食干预组之一：对照组（低脂饮食）、富含特级初榨橄榄油的 MeDiet（MeDiet+VOO）或富含坚果的 MeDiet（MeDiet+Nuts）。干预 3 年后测量血浆 BDNF 水平。使用广义线性模型比较每个干预组 BDNF 的多变量调整均值。拟合逻辑回归模型评估饮食干预与血浆 BDNF 值较低（<13μg/ml，第 10 百分位数）的可能性之间的关联。根据基线时不同疾病的患病率对样本进行分层后，重复了分析。
分配到两种 MeDiet 的参与者的血浆 BDNF 水平较高，但无统计学意义。与对照组相比，分配到 MeDiet+Nuts 的参与者血浆 BDNF 值较低（<13μg/ml）的风险显著降低（比值比（OR）=0.22；95%置信区间（CI）=0.05-0.90）。在基线时患有抑郁症的参与者中，分配到 MeDiet+Nuts 的参与者的 BDNF 水平显著升高。
坚持 MeDiet 与抑郁患者血浆 BDNF 浓度的改善相关。
