Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden.
Acta Biomater. 2012 Feb;8(2):579-88. doi: 10.1016/j.actbio.2011.09.022. Epub 2011 Oct 4.
The development of new adhesive wound care products intended for an application over a prolonged time requires good water transporting properties of the adhesive for the maintenance of a suitable environment around the wound. The ability of polydimethylsiloxane (PDMS)-based silicone films to transport water has led to its use in skin pressure-sensitive adhesives and it would be advantageous to find ways for controlling or increasing water transport across PDMS films in order to be able to develop improved skin adhesives. In this study we present a way to increase water transport in such films by the addition of hydrophilic excipients. Three hydrophilic additives, highly water-soluble sucrose and the two superabsorbent polymers (SAP) Carbopol® and Pemulen™, were investigated. The effect of the excipients was characterized by water transport studies, swelling tests, scanning electron microscopy imaging and confocal microscopy. The cross-linked polymers, primarily Pemulen™, were efficient water transport enhancers, whereas sucrose did not show any effect. The effect of the additives seemed to correlate with their water binding capacity. For SAPs the formation of a percolating structure by swollen polymer was also suggested, which enhances water penetration by the higher volume fraction of areas with a higher diffusion constant (swollen SAP), leading to a faster transport through the entire film.
新型粘性伤口护理产品的开发旨在长时间应用，这就需要粘性材料具有良好的输水性能，以维持伤口周围的适宜环境。基于聚二甲基硅氧烷（PDMS）的硅酮薄膜具有输水能力，因此被用于皮肤压敏粘合剂中。如果能够找到控制或增加 PDMS 薄膜输水的方法，就有可能开发出改良的皮肤粘合剂。在本研究中，我们提出了一种通过添加亲水性赋形剂来增加此类薄膜输水能力的方法。研究了三种亲水性添加剂：高水溶性的蔗糖以及两种高吸水性聚合物（SAP）Carbopol®和 Pemulen™。通过输水研究、溶胀试验、扫描电子显微镜成像和共聚焦显微镜研究了赋形剂的作用。交联聚合物（主要是 Pemulen™）是有效的输水增强剂，而蔗糖则没有任何效果。添加剂的作用似乎与其水结合能力相关。对于 SAP，还提出了由溶胀聚合物形成的渗透结构，这通过具有更高扩散常数的区域（溶胀 SAP）的更高体积分数增强了水的渗透，从而使整个薄膜的传输速度更快。
