Living Proof, Inc., Cambridge, Massachusetts 02142, USA.
Olivo Laboratories, LLC, Cambridge, Massachusetts 02142, USA.
Nat Mater. 2016 Aug;15(8):911-8. doi: 10.1038/nmat4635. Epub 2016 May 9.
We report the synthesis and application of an elastic, wearable crosslinked polymer layer (XPL) that mimics the properties of normal, youthful skin. XPL is made of a tunable polysiloxane-based material that can be engineered with specific elasticity, contractility, adhesion, tensile strength and occlusivity. XPL can be topically applied, rapidly curing at the skin interface without the need for heat- or light-mediated activation. In a pilot human study, we examined the performance of a prototype XPL that has a tensile modulus matching normal skin responses at low strain (<40%), and that withstands elongations exceeding 250%, elastically recoiling with minimal strain-energy loss on repeated deformation. The application of XPL to the herniated lower eyelid fat pads of 12 subjects resulted in an average 2-grade decrease in herniation appearance in a 5-point severity scale. The XPL platform may offer advanced solutions to compromised skin barrier function, pharmaceutical delivery and wound dressings.
我们报告了一种弹性、可穿戴的交联聚合物层 (XPL) 的合成和应用，该聚合物层模拟了正常、年轻皮肤的特性。XPL 由一种可调谐的聚硅氧烷基材料制成，可以通过特定的弹性、收缩性、附着力、拉伸强度和密封性进行工程设计。XPL 可以通过局部应用，在皮肤界面上快速固化，而无需热或光介导的激活。在一项初步的人体研究中，我们研究了一种原型 XPL 的性能，该原型 XPL 的拉伸模量与低应变（<40%）下的正常皮肤反应相匹配，并且能够承受超过 250%的伸长率，在反复变形时弹性回弹，应变能损失最小。将 XPL 应用于 12 名受试者的下眼睑疝出的脂肪垫，可使疝出外观在 5 分严重程度量表上平均降低 2 级。XPL 平台可能为受损的皮肤屏障功能、药物输送和伤口敷料提供先进的解决方案。
