放射性标记抗体治疗免疫功能正常小鼠的早期和已建立的新型隐球菌感染。
Treatment of early and established Cryptococcus neoformans infection with radiolabeled antibodies in immunocompetent mice.
机构信息
Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
出版信息
Antimicrob Agents Chemother. 2012 Jan;56(1):552-4. doi: 10.1128/AAC.00473-11. Epub 2011 Oct 17.
Abstract
We investigated the utility of radioimmunotherapy (RIT) in early and established cryptococcal infection in immunocompetent mice. RIT with (213)Bi-18B7 antibody completely eliminated fungus from mouse lungs and brains for early infection, while (188)Re-18B7 significantly reduced CFU in the lungs or both lungs and brains during early and established infection, respectively. The results point to the independence of RIT of the immune status of the host, which is encouraging for translation of this strategy into the clinic.
摘要
我们研究了放射免疫疗法（RIT）在免疫功能正常的小鼠中早期和已建立的隐球菌感染中的应用。用（213）Bi-18B7 抗体进行 RIT 治疗可完全清除早期感染小鼠肺部和脑部的真菌，而（188）Re-18B7 分别在早期和已建立的感染时显著降低肺部或肺部和脑部的 CFU。这些结果表明 RIT 独立于宿主的免疫状态，这对于将该策略转化为临床应用是令人鼓舞的。
相似文献
1
Treatment of early and established Cryptococcus neoformans infection with radiolabeled antibodies in immunocompetent mice.放射性标记抗体治疗免疫功能正常小鼠的早期和已建立的新型隐球菌感染。
Antimicrob Agents Chemother. 2012 Jan;56(1):552-4. doi: 10.1128/AAC.00473-11. Epub 2011 Oct 17.
2
Radioimmunotherapy is more effective than antifungal treatment in experimental cryptococcal infection.放射性免疫疗法比抗真菌治疗更有效治疗实验性隐球菌感染。
J Infect Dis. 2010 Aug 15;202(4):633-7. doi: 10.1086/654813.
3
Evaluation of acute hematologic and long-term pulmonary toxicities of radioimmunotherapy of Cryptococcus neoformans infection in murine models.鼠模型中新隐球菌感染放射免疫疗法的急性血液学和长期肺部毒性评估
Antimicrob Agents Chemother. 2004 Mar;48(3):1004-6. doi: 10.1128/AAC.48.3.1004-1006.2004.
4
Radioimmunotherapy is effective against high-inoculum Cryptococcus neoformans infection in mice and does not select for radiation-resistant cryptococcal cells.放射免疫疗法对小鼠高接种量新型隐球菌感染有效，且不会筛选出抗辐射的隐球菌细胞。
Antimicrob Agents Chemother. 2009 Apr;53(4):1679-82. doi: 10.1128/AAC.01334-08. Epub 2009 Jan 12.
5
Comparative evaluation of capsular polysaccharide-specific IgM and IgG antibodies and F(ab')2 and Fab fragments as delivery vehicles for radioimmunotherapy of fungal infection.荚膜多糖特异性IgM和IgG抗体以及F(ab')2和Fab片段作为真菌感染放射免疫治疗递送载体的比较评估。
Clin Cancer Res. 2007 Sep 15;13(18 Pt 2):5629s-5635s. doi: 10.1158/1078-0432.CCR-07-0870.
6
7
Interaction of radiolabeled antibodies with fungal cells and components of the immune system in vitro and during radioimmunotherapy for experimental fungal infection.放射性标记抗体与真菌细胞及免疫系统成分在体外以及实验性真菌感染的放射免疫治疗过程中的相互作用。
J Infect Dis. 2006 May 15;193(10):1427-36. doi: 10.1086/503369. Epub 2006 Apr 13.
8
Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection.抗真菌葡糖神经酰胺单克隆抗体可保护小鼠免受新型隐球菌致死性感染。
Clin Vaccine Immunol. 2007 Oct;14(10):1372-6. doi: 10.1128/CVI.00202-07. Epub 2007 Aug 22.
9
Preclinical testing of radiopharmaceuticals for novel applications in HIV, bacterial and fungal infectious diseases.用于HIV、细菌和真菌感染性疾病新应用的放射性药物的临床前测试。
Q J Nucl Med Mol Imaging. 2015 Sep;59(3):317-26. Epub 2015 Jul 22.
10
Protection of mice against experimental cryptococcosis by anti-Cryptococcus neoformans monoclonal antibody.抗新型隐球菌单克隆抗体对小鼠实验性隐球菌病的保护作用。
Infect Immun. 1987 Mar;55(3):749-52. doi: 10.1128/iai.55.3.749-752.1987.
引用本文的文献
1
Antifungal immunity: advances in PRR recognition, adaptive responses, and immune-based therapies.抗真菌免疫：模式识别受体识别、适应性反应及基于免疫的治疗进展
Sci China Life Sci. 2025 Mar 5. doi: 10.1007/s11427-024-2835-y.
2
Methods of Cryptococcal Polysaccharide Analysis Using ELISA.基于 ELISA 的隐球菌多糖分析方法。
Methods Mol Biol. 2024;2775:239-255. doi: 10.1007/978-1-0716-3722-7_16.
3
Radioimmunotherapy of Blastomycosis in a Mouse Model With a (1→3)-β-Glucans Targeting Antibody.用靶向（1→3）-β-葡聚糖的抗体对小鼠芽生菌病模型进行放射免疫治疗。
Front Microbiol. 2020 Feb 7;11:147. doi: 10.3389/fmicb.2020.00147. eCollection 2020.
4
Radioimmunotherapy as a Novel Approach in HIV, Bacterial, and Fungal Infectious Diseases.放射性免疫疗法作为一种治疗 HIV、细菌和真菌感染性疾病的新方法。
Cancer Biother Radiopharm. 2018 Oct;33(8):330-335. doi: 10.1089/cbr.2018.2481. Epub 2018 Aug 22.
5
Radiolabeled antibodies for therapy of infectious diseases.用于传染病治疗的放射性标记抗体。
Microbiol Spectr. 2014 Nov;2(6):0023. doi: 10.1128/microbiolspec.AID-0023-2014.
6
Cryptococcosis: epidemiology, fungal resistance, and new alternatives for treatment. cryptococcosis：流行病学、真菌耐药性和新的治疗选择。
Eur J Clin Microbiol Infect Dis. 2013 Nov;32(11):1377-91. doi: 10.1007/s10096-013-1915-8. Epub 2013 Jul 4.
7
Radioimmunotherapy of Cryptococcus neoformans spares bystander mammalian cells.放射性免疫疗法可使隐球菌免于伤害旁观的哺乳动物细胞。
Future Microbiol. 2013 Sep;8(9):1081-9. doi: 10.2217/fmb.13.79.
8
New insights in the prevention, diagnosis, and treatment of cryptococcal meningitis.新型隐球菌性脑膜炎的预防、诊断和治疗新视角。
Curr HIV/AIDS Rep. 2012 Sep;9(3):267-77. doi: 10.1007/s11904-012-0127-7.
本文引用的文献
1
Radioimmunotherapy is more effective than antifungal treatment in experimental cryptococcal infection.放射性免疫疗法比抗真菌治疗更有效治疗实验性隐球菌感染。
J Infect Dis. 2010 Aug 15;202(4):633-7. doi: 10.1086/654813.
2
Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain.实时成像观察新型隐球菌在小鼠脑中的捕获和脲酶依赖的迁移。
J Clin Invest. 2010 May;120(5):1683-93. doi: 10.1172/JCI41963. Epub 2010 Apr 26.
3
Radioimmunotherapy of infectious diseases.传染病的放射免疫疗法。
Semin Nucl Med. 2009 Mar;39(2):146-53. doi: 10.1053/j.semnuclmed.2008.10.007.
4
Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS.对全球感染艾滋病毒/艾滋病者中隐球菌性脑膜炎当前负担的估计。
AIDS. 2009 Feb 20;23(4):525-30. doi: 10.1097/QAD.0b013e328322ffac.
5
Radioimmunotherapy is effective against high-inoculum Cryptococcus neoformans infection in mice and does not select for radiation-resistant cryptococcal cells.放射免疫疗法对小鼠高接种量新型隐球菌感染有效，且不会筛选出抗辐射的隐球菌细胞。
Antimicrob Agents Chemother. 2009 Apr;53(4):1679-82. doi: 10.1128/AAC.01334-08. Epub 2009 Jan 12.
6
Radiofungicidal effects of external gamma radiation and antibody-targeted beta and alpha radiation on Cryptococcus neoformans.外部γ辐射以及抗体靶向β和α辐射对新型隐球菌的放射杀菌作用。
Antimicrob Agents Chemother. 2008 Jun;52(6):2232-5. doi: 10.1128/AAC.01245-07. Epub 2008 Mar 31.
7
Interaction of radiolabeled antibodies with fungal cells and components of the immune system in vitro and during radioimmunotherapy for experimental fungal infection.放射性标记抗体与真菌细胞及免疫系统成分在体外以及实验性真菌感染的放射免疫治疗过程中的相互作用。
J Infect Dis. 2006 May 15;193(10):1427-36. doi: 10.1086/503369. Epub 2006 Apr 13.
8
Perspectives on cancer therapy with radiolabeled monoclonal antibodies.放射性标记单克隆抗体在癌症治疗中的应用前景
J Nucl Med. 2005 Jan;46 Suppl 1:115S-27S.
9
Evaluation of acute hematologic and long-term pulmonary toxicities of radioimmunotherapy of Cryptococcus neoformans infection in murine models.鼠模型中新隐球菌感染放射免疫疗法的急性血液学和长期肺部毒性评估
Antimicrob Agents Chemother. 2004 Mar;48(3):1004-6. doi: 10.1128/AAC.48.3.1004-1006.2004.
10
Ionizing radiation delivered by specific antibody is therapeutic against a fungal infection.由特异性抗体传递的电离辐射对真菌感染具有治疗作用。
Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10942-7. doi: 10.1073/pnas.1731272100. Epub 2003 Aug 20.
Zotero 插件