乌氏衣酸对近平滑念珠菌和葡萄牙念珠菌的影响。
Effect of usnic acid on Candida orthopsilosis and C. parapsilosis.
机构信息
Universidade Estadual Paulista, UNESP, Araraquara, SP, Brazil.
出版信息
Antimicrob Agents Chemother. 2012 Jan;56(1):595-7. doi: 10.1128/AAC.05348-11. Epub 2011 Oct 17.
Abstract
The activity of usnic acid against Candida orthopsilosis and Candida parapsilosis on planktonic and biofilm conditions was investigated by using a broth microdilution and microplate methods. Potent in vitro activities against different Candida species were obtained. The metabolic activity of sessile cells of C. parapsilosis complex was reduced by 80% at four times the 80% inhibitory concentration. The in vitro studies support further efforts to determine whether usnic acid can be used clinically to cure patients with Candida infections.
摘要
采用肉汤微量稀释和微量板方法研究了对蹠节菌酸对浮游和生物膜条件下近平滑念珠菌和中间型念珠菌的活性。对不同念珠菌属的体外活性均较强。80%抑制浓度的 4 倍时，中间型假丝酵母复合体的定殖细胞代谢活性降低了 80%。体外研究支持进一步努力确定对蹠节菌酸是否可临床用于治疗念珠菌感染患者。
相似文献
1
Effect of usnic acid on Candida orthopsilosis and C. parapsilosis.乌氏衣酸对近平滑念珠菌和葡萄牙念珠菌的影响。
Antimicrob Agents Chemother. 2012 Jan;56(1):595-7. doi: 10.1128/AAC.05348-11. Epub 2011 Oct 17.
2
Azole derivatives with naphthalene showing potent antifungal effects against planktonic and biofilm forms of Candida spp.: an in vitro and in silico study.具有萘结构的唑类衍生物对念珠菌属浮游菌和生物膜形式均显示出强效抗真菌作用：一项体外和计算机模拟研究。
Int Microbiol. 2021 Jan;24(1):93-102. doi: 10.1007/s10123-020-00144-y. Epub 2020 Sep 5.
3
The effect of melatonin on antifungal susceptibility in planktonic and biofilm forms of Candida strains isolated from clinical samples.褪黑素对从临床样本中分离出的念珠菌菌株浮游和生物膜形式抗真菌药敏性的影响。
Med Mycol. 2019 Jan 1;57(1):45-51. doi: 10.1093/mmy/myx157.
4
Anticandidal efficacy of cinnamon oil against planktonic and biofilm cultures of Candida parapsilosis and Candida orthopsilosis.肉桂油对近平滑念珠菌和葡萄牙念珠菌浮游和生物膜培养的抗真菌效果。
Mycopathologia. 2011 Dec;172(6):453-64. doi: 10.1007/s11046-011-9448-0. Epub 2011 Jul 15.
5
In vitro activity of micafungin against biofilms of Candida albicans, Candida glabrata, and Candida parapsilosis at different stages of maturation.米卡芬净对白色念珠菌、光滑念珠菌和近平滑念珠菌不同成熟阶段生物膜的体外活性。
Folia Microbiol (Praha). 2018 Mar;63(2):209-216. doi: 10.1007/s12223-017-0555-2. Epub 2017 Oct 5.
6
Comparative in vitro activities of seven antifungal drugs against clinical isolates of Candida parapsilosis complex.七种抗真菌药物对近平滑念珠菌临床分离株的体外比较活性。
J Mycol Med. 2020 Sep;30(3):100968. doi: 10.1016/j.mycmed.2020.100968. Epub 2020 Apr 4.
7
In vitro and in vivo effects of echinocandins against Candida parapsilosis sensu stricto, Candida orthopsilosis and Candida metapsilosis.棘白菌素类药物对近平滑念珠菌、近平滑假丝酵母和中间假丝酵母的体外和体内作用。
J Antimicrob Chemother. 2012 Sep;67(9):2195-202. doi: 10.1093/jac/dks180. Epub 2012 May 25.
8
The inhibitory effects of aureobasidin A on Candida planktonic and biofilm cells.金核菌素 A 对浮游和生物膜状态念珠菌的抑制作用。
Mycoses. 2013 Mar;56(2):150-6. doi: 10.1111/j.1439-0507.2012.02225.x. Epub 2012 Aug 12.
9
Antifungal susceptibility and virulence of Candida parapsilosis species complex: an overview of their pathogenic potential.近平滑念珠菌复合体的抗真菌药敏性和毒力：对其致病潜力的概述。
J Med Microbiol. 2018 Jul;67(7):903-914. doi: 10.1099/jmm.0.000756. Epub 2018 May 30.
10
Evaluation of baicalein, chitosan and usnic acid effect on Candida parapsilosis and Candida krusei biofilm using a Cellavista device.使用Cellavista设备评估黄芩素、壳聚糖和松萝酸对近平滑念珠菌和克鲁斯念珠菌生物膜的影响。
J Microbiol Methods. 2015 Nov;118:106-12. doi: 10.1016/j.mimet.2015.09.002. Epub 2015 Sep 8.
引用本文的文献
1
Discovery of semisynthetic derivatives of ()- and ()-usnic acids as potential antifungal agents against and .（±）-松萝酸半合成衍生物作为抗 和 的潜在抗真菌剂的发现。
RSC Med Chem. 2025 Jul 10. doi: 10.1039/d5md00457h.
2
Controlling Oral Polymicrobial Biofilm Using Usnic Acid on the Surface of Titanium in the Artificial Saliva Media.在人工唾液介质中，利用扁枝衣酸控制钛表面的口腔多微生物生物膜
Antibiotics (Basel). 2025 Jan 22;14(2):115. doi: 10.3390/antibiotics14020115.
3
Lichen and Its Microbiome as an Untapped Source of Anti-Biofilm Compounds.地衣及其微生物群落作为抗生物膜化合物的未开发来源。
Chem Biodivers. 2025 Apr;22(4):e202401557. doi: 10.1002/cbdv.202401557. Epub 2024 Dec 20.
4
Development, Optimization, and Evaluation of New Gel Formulations with Cyclodextrin Complexes and Volatile Oils with Antimicrobial Activity.具有抗菌活性的环糊精复合物和挥发油新型凝胶制剂的开发、优化与评价
Gels. 2024 Oct 10;10(10):645. doi: 10.3390/gels10100645.
5
Usnic Acid-Loaded Magnetite Nanoparticles-A Comparative Study between Synthesis Methods.载熊果素磁铁矿纳米粒子的合成方法比较研究。
Molecules. 2023 Jul 4;28(13):5198. doi: 10.3390/molecules28135198.
6
Effectiveness of a Self-Decontaminating Coating Containing Usnic Acid in Reducing Environmental Microbial Load in Tertiary-Care Hospitals.三羧酸循环在细胞呼吸中的作用。
Int J Environ Res Public Health. 2023 Apr 7;20(8):5434. doi: 10.3390/ijerph20085434.
7
Phytochemical composition, antimicrobial activities, and cholinesterase inhibitory properties of the lichen Vain.地衣Vain.的植物化学成分、抗菌活性及胆碱酯酶抑制特性
Front Chem. 2023 Jan 6;10:1063645. doi: 10.3389/fchem.2022.1063645. eCollection 2022.
8
Antimicrobial Effectiveness of an Usnic-Acid-Containing Self-Decontaminating Coating on Underground Metro Surfaces in Athens.含松萝酸的自净化涂层对雅典地铁地下表面的抗菌效果
Microorganisms. 2022 Nov 11;10(11):2233. doi: 10.3390/microorganisms10112233.
9
Quatsomes Formulated with l-Prolinol-Derived Surfactants as Antibacterial Nanocarriers of (+)-Usnic Acid with Antioxidant Activity.以L-脯氨醇衍生表面活性剂配制的脂质体作为具有抗氧化活性的（+）-松萝酸抗菌纳米载体
ACS Appl Nano Mater. 2022 May 27;5(5):6140-6148. doi: 10.1021/acsanm.1c04365. Epub 2022 May 9.
10
Lichen Polyphenolic Compounds for the Eradication of Biofilms.用于消除生物膜的地衣多酚化合物。
Front Cell Infect Microbiol. 2021 Sep 16;11:698883. doi: 10.3389/fcimb.2021.698883. eCollection 2021.
本文引用的文献
1
Vital signs: central line-associated blood stream infections--United States, 2001, 2008, and 2009.生命体征：中心静脉导管相关血流感染——美国，2001 年、2008 年和 2009 年。
MMWR Morb Mortal Wkly Rep. 2011 Mar 4;60(8):243-8.
2
Frequency of catheter related infections in haemodialysed uraemic patients.血液透析尿毒症患者导管相关感染的发生率
J Pak Med Assoc. 2010 Aug;60(8):671-5.
3
Epidemiology of opportunistic fungal infections in Latin America.拉丁美洲机会性真菌感染的流行病学。
Clin Infect Dis. 2010 Sep 1;51(5):561-70. doi: 10.1086/655683.
4
Current results on biological activities of lichen secondary metabolites: a review.当前关于地衣次生代谢产物生物活性的研究进展：综述。
Z Naturforsch C J Biosci. 2010 Mar-Apr;65(3-4):157-73. doi: 10.1515/znc-2010-3-401.
5
Antibacterial activities of Ramalin, usnic acid and its three derivatives isolated from the Antarctic lichen Ramalina terebrata.南极地衣拉玛灵中分离得到的拉玛灵、地衣酸及其三种衍生物的抗菌活性。
Z Naturforsch C J Biosci. 2010 Jan-Feb;65(1-2):34-8. doi: 10.1515/znc-2010-1-206.
6
Effect of cinnamon oil on icaA expression and biofilm formation by Staphylococcus epidermidis.肉桂油对表皮葡萄球菌icaA 表达和生物膜形成的影响。
Appl Environ Microbiol. 2009 Nov;75(21):6850-5. doi: 10.1128/AEM.00875-09. Epub 2009 Sep 11.
7
Determinants of mortality in non-neutropenic ICU patients with candidaemia.非中性粒细胞减少症 ICU 患者念珠菌血症的死亡率决定因素。
Crit Care. 2009;13(4):R115. doi: 10.1186/cc7964. Epub 2009 Jul 13.
8
A simple and reproducible 96-well plate-based method for the formation of fungal biofilms and its application to antifungal susceptibility testing.一种基于96孔板的简单且可重复的真菌生物膜形成方法及其在抗真菌药敏试验中的应用。
Nat Protoc. 2008;3(9):1494-500. doi: 10.1038/nport.2008.141.
9
Reduced biocide susceptibility in Candida albicans biofilms.白色念珠菌生物膜中杀菌剂敏感性降低。
Antimicrob Agents Chemother. 2008 Sep;52(9):3411-3. doi: 10.1128/AAC.01656-07. Epub 2008 Jun 23.
10
Geographic distribution and antifungal susceptibility of the newly described species Candida orthopsilosis and Candida metapsilosis in comparison to the closely related species Candida parapsilosis.新描述的近平滑念珠菌和季也蒙念珠菌与密切相关的副平滑念珠菌相比的地理分布及抗真菌药敏性
J Clin Microbiol. 2008 Aug;46(8):2659-64. doi: 10.1128/JCM.00803-08. Epub 2008 Jun 18.
Zotero 插件