Institute for Medical Virology, University Hospital, Paul Ehrlich-Strasse 40, 60596, Frankfurt am Main, Germany.
Med Microbiol Immunol. 2012 May;201(2):171-5. doi: 10.1007/s00430-011-0218-x. Epub 2011 Oct 18.
Hepatitis E virus (HEV) is largely confined to travelers returning from endemic areas, but the number of autochthonous cases of acute HEV infections in developed countries is increasing. Reservoirs for HEV are surface water, wild boar meat, and raw or undercooked pork meat. Usually, hepatitis E is a self-limiting disease presenting with acute hepatitis as a major clinical symptom. The seroprevalence of anti-HEV-IgG was investigated in 833 serum samples routinely collected from patients admitted to the university hospital in Frankfurt a. M., Germany (FFM) between 01.06.2008 and 31.12.2010. After determination of overall seroprevalence, we tested serum samples from patients diagnosed with acute elevation of liver enzymes (AELE), psychiatric (PSYCH), infectiological patients and serum samples from the red-cross blood donor service in FFM for anti-HEV-IgG using an ELISA. Between 01.06.2008 and 31.12.2010, 833 serum samples were analyzed for anti-HEV-IgG using an ELISA. We observed an overall seroprevalence of anti-HEV-IgG of 11.2% (95%CI: 9.6-13.2). Significantly higher rate of seropositivity was found in the group of PSYCH (26.0%; 95%CI: 14.63-40.34) and AELE (30.0%; 95%CI: 17.86-44.61). Overall seroprevalence of anti-HEV-IgG in FFM is higher than in Germany on average. The group of AELE and PSYCH shows significantly more often marker of HEV infections than other groups in our collective.
戊型肝炎病毒 (HEV) 主要局限于从流行地区返回的旅行者，但发达国家的本地急性 HEV 感染病例数量正在增加。HEV 的储主是地表水、野猪肉和生的或未煮熟的猪肉。通常，戊型肝炎是一种自限性疾病，主要临床症状为急性肝炎。我们调查了德国法兰克福大学医院（FFM）在 2008 年 6 月 1 日至 2010 年 12 月 31 日期间常规收治的 833 例患者血清样本中抗-HEV-IgG 的血清流行率。在确定总血清流行率后，我们使用 ELISA 检测了诊断为急性肝酶升高（AELE）、精神科（PSYCH）、传染病患者的患者血清样本和 FFM 红十字会献血服务的血清样本中的抗-HEV-IgG。2008 年 6 月 1 日至 2010 年 12 月 31 日期间，我们使用 ELISA 分析了 833 例血清样本中的抗-HEV-IgG。我们观察到抗-HEV-IgG 的总血清流行率为 11.2%（95%CI：9.6-13.2）。PSYCH 组（26.0%；95%CI：14.63-40.34）和 AELE 组（30.0%；95%CI：17.86-44.61）的血清阳性率明显更高。FFM 的抗-HEV-IgG 总血清流行率高于德国平均水平。AELE 和 PSYCH 组在我们的研究中比其他组更经常出现 HEV 感染标志物。
