Homburg R, West C, Torresani T, Jacobs H S
Cobbold Laboratories, University College and Middlesex School of Medicine, London, UK.
Clin Endocrinol (Oxf). 1990 Jun;32(6):781-5. doi: 10.1111/j.1365-2265.1990.tb00925.x.
One intramuscular injection of biosynthetic human growth hormone (24 IU), administered on the first day of gonadotrophin treatment for ovulation induction, significantly augmented the ovarian response to gonadotrophic stimulation in seven patients. Compared with a protocol involving six injections of 24 IU of GH given on alternate days to the same patients, the smaller dose had an intermediate but highly significant effect in reducing the amount, duration of treatment and daily effective dose of hMG needed to induce ovulation. The difference between the effect of the one-dose and six-dose protocols was small. The action of growth hormone on the human ovary, probably mediated by insulin-like growth factor-1 (IGF-1), appears effective in enhancing the response to gonadotrophin therapy even when given in a single dose.
在促性腺激素治疗诱导排卵的第一天，单次肌内注射生物合成人生长激素（24国际单位），显著增强了7名患者卵巢对促性腺激素刺激的反应。与对同一患者每隔一天注射6次24国际单位生长激素的方案相比，较小剂量在减少诱导排卵所需的人绝经期促性腺激素用量、治疗持续时间和每日有效剂量方面具有中等但高度显著的效果。单剂量方案和六剂量方案的效果差异很小。生长激素对人类卵巢的作用，可能由胰岛素样生长因子-1（IGF-1）介导，即使单次给药，似乎也能有效增强对促性腺激素治疗的反应。
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