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本文引用的文献

1
Elevated serum free light chains are associated with event-free and overall survival in two independent cohorts of patients with diffuse large B-cell lymphoma.血清游离轻链升高与弥漫性大 B 细胞淋巴瘤患者的无事件生存和总生存相关。
J Clin Oncol. 2011 Apr 20;29(12):1620-6. doi: 10.1200/JCO.2010.29.4413. Epub 2011 Mar 7.
2
International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders.国际骨髓瘤工作组关于多发性骨髓瘤及相关疾病血清游离轻链分析的指南。
Leukemia. 2009 Feb;23(2):215-24. doi: 10.1038/leu.2008.307. Epub 2008 Nov 20.
3
Serum-free light chain-a new biomarker for patients with B-cell non-Hodgkin lymphoma and chronic lymphocytic leukemia.游离轻链——B细胞非霍奇金淋巴瘤和慢性淋巴细胞白血病患者的一种新生物标志物。
Transl Res. 2007 Apr;149(4):231-5. doi: 10.1016/j.trsl.2006.11.001.
4
Immunoglobulin free light chains and solitary plasmacytoma of bone.免疫球蛋白游离轻链与骨孤立性浆细胞瘤
Blood. 2006 Sep 15;108(6):1979-83. doi: 10.1182/blood-2006-04-015784. Epub 2006 Jun 1.
5
Absolute values of immunoglobulin free light chains are prognostic in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation.免疫球蛋白游离轻链的绝对值对接受外周血干细胞移植的原发性系统性淀粉样变性患者具有预后价值。
Blood. 2006 Apr 15;107(8):3378-83. doi: 10.1182/blood-2005-07-2922. Epub 2006 Jan 5.
6
Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance.血清游离轻链比值是意义未明的单克隆丙种球蛋白病病情进展的独立危险因素。
Blood. 2005 Aug 1;106(3):812-7. doi: 10.1182/blood-2005-03-1038. Epub 2005 Apr 26.
7
Diagnostic performance of quantitative kappa and lambda free light chain assays in clinical practice.定量κ和λ游离轻链检测在临床实践中的诊断性能。
Clin Chem. 2005 May;51(5):878-81. doi: 10.1373/clinchem.2004.046870. Epub 2005 Mar 17.
8
Quantitative analysis of serum free light chains. A new marker for the diagnostic evaluation of primary systemic amyloidosis.血清游离轻链的定量分析。一种用于原发性系统性淀粉样变性诊断评估的新标志物。
Am J Clin Pathol. 2003 Feb;119(2):274-8. doi: 10.1309/LYWM-47K2-L8XY-FFB3.
9
Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light chains: relative sensitivity for detection of monoclonal light chains.游离κ和游离λ免疫球蛋白轻链的血清参考区间及诊断范围：检测单克隆轻链的相对敏感性
Clin Chem. 2002 Sep;48(9):1437-44.
10
Highly sensitive, automated immunoassay for immunoglobulin free light chains in serum and urine.用于血清和尿液中游离免疫球蛋白轻链的高灵敏度自动化免疫测定法。
Clin Chem. 2001 Apr;47(4):673-80.

血清游离轻链升高与霍奇金淋巴瘤患者无事件生存和总生存不良相关。

Elevated serum free light chains are associated with inferior event free and overall survival in Hodgkin lymphoma.

机构信息

Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

出版信息

Am J Hematol. 2011 Dec;86(12):998-1000. doi: 10.1002/ajh.22168. Epub 2011 Oct 17.

DOI:10.1002/ajh.22168
PMID:22006790
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3588858/
Abstract

The serum free light chain (FLC) assay quantitates free immunoglobulin kappa and lambda light chains, which has prognostic value in plasma cell dyscrasias. However, there is limited data on serum FLC in lymphoid malignancies. We analyzed the association of pretreatment FLC with event-free survival (EFS) and overall survival (OS) in 100 patients with Hodgkin lymphoma (HL). Elevated polyclonal FLC were present in 30% of patients; these patients had an inferior EFS (HR = 4.84; 95% CI: 1.84-12.7) and OS (HR = 8.87; 95% CI: 2.35-33.52) compared to patients with normal FLC. Further studies of FLC in HL are warranted.

摘要

血清游离轻链（FLC）检测定量游离免疫球蛋白 κ 和 λ 轻链，其在浆细胞疾病中有预后价值。然而，关于淋巴恶性肿瘤的血清 FLC 数据有限。我们分析了 100 例霍奇金淋巴瘤（HL）患者的预处理 FLC 与无事件生存（EFS）和总生存（OS）的关系。30%的患者存在多克隆 FLC 升高；与 FLC 正常的患者相比，这些患者的 EFS（HR=4.84；95%CI：1.84-12.7）和 OS（HR=8.87；95%CI：2.35-33.52）更差。进一步研究 FLC 在 HL 中的作用是必要的。