Liu Jian-Tao, Yang Yong, Guo Xiao-Gang, Chen Miao, Ding Huan-Zhong, Chen Yong-Long, Wang Min-Ru
Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Dongwuxue Yanjiu. 2011 Oct;32(5):485-91. doi: 10.3724/SP.J.1141.2011.05485.
Accumulated evidence indicates that the activating transcription factor 4 (atf4) is a developmentally relevant gene. Here, we report on the characterization of atf4 in Xenopus embryos, which is differentially expressed in the central nervous system, eyes, blood, and the pronephros, as well as in developing endodermal organs such as the stomach, duodenum, liver, and pancreas. Ectopic expression of atf4 in the animal hemisphere of Xenopus embryos had no obvious effects on the induction of neural progenitors, but suppressed neurogenesis and eye formation without promoting apoptosis. Our data suggest that tightly controlled atf4 activities may be crucial for normal neurogenesis and early eye patterning.
越来越多的证据表明，激活转录因子4（ATF4）是一个与发育相关的基因。在此，我们报告非洲爪蟾胚胎中ATF4的特征，它在中枢神经系统、眼睛、血液、前肾以及发育中的内胚层器官（如胃、十二指肠、肝脏和胰腺）中差异表达。在非洲爪蟾胚胎的动物半球异位表达ATF4对神经祖细胞的诱导没有明显影响，但抑制了神经发生和眼睛形成，且未促进细胞凋亡。我们的数据表明，严格控制的ATF4活性可能对正常神经发生和早期眼睛模式形成至关重要。
