de Boer A G, van Hoogdalem E J, Breimer D D
Division of Pharmacology, University of Leiden, The Netherlands.
Eur J Drug Metab Pharmacokinet. 1990 Apr-Jun;15(2):155-7. doi: 10.1007/BF03190198.
The application of enhancers for improvement of drug absorption via the nasal, transdermal and rectal route are outlined. The importance of the relation between the time course of the enhancing effect and the desired plasma - concentration - time profile of the drug is stressed as well as the need to pay more attention to the safety aspects of absorption enhancers.
概述了增强剂在改善药物经鼻、经皮和直肠途径吸收方面的应用。强调了增强作用的时间进程与药物所需的血药浓度-时间曲线之间关系的重要性，以及需要更加关注吸收增强剂的安全性方面。
