van Hoogdalem E J, Stijnen A M, de Boer A G, Breimer D D
Center for Bio-Pharmaceutical Sciences, Sylvius Laboratories, State University of Leiden, The Netherlands.
J Pharm Pharmacol. 1988 May;40(5):329-32. doi: 10.1111/j.2042-7158.1988.tb05261.x.
The enhancing effect of the medium chain glyceride preparation MGK on the rectal absorption of the cephalosporin antibiotic cefazolin sodium was evaluated in relation to the rate of delivery. Cefazolin sodium proved to be absorbed to a small extent (15 to 27%) after rectal administration without MGK. Bolus administration with MGK enhanced rate and extent of cefazolin sodium absorption, resulting in a bioavailability of 57 +/- 26%. Linear infusion of 3 mg cefazolin sodium with MGK in 32 min produced complete absorption of the antibiotic (102 +/- 7%), but absorption occurred slower in comparison with bolus delivery. The rate of administration proved to be an important variable of the absorption enhancing effect of MGK.
就给药速率而言，评估了中链甘油酯制剂MGK对头孢菌素抗生素头孢唑林钠直肠吸收的增强作用。在没有MGK的情况下，直肠给药后头孢唑林钠的吸收程度较小（15%至27%）。与MGK推注给药可提高头孢唑林钠的吸收速率和程度，生物利用度为57±26%。在32分钟内将3mg头孢唑林钠与MGK进行线性输注可使抗生素完全吸收（102±7%），但与推注给药相比，吸收速度较慢。给药速率被证明是MGK吸收增强作用的一个重要变量。
