School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia.
J Infect Dis. 2011 Dec 15;204(12):1927-35. doi: 10.1093/infdis/jir659. Epub 2011 Oct 17.
Most patients with human immunodeficiency virus (HIV) who remain CD4(+) T-cell deficient on antiretroviral therapy (ART) exhibit marked immune activation. As CD4(+) T-cell activation may be mediated by microbial translocation or interferon-alpha (IFN-α), we examined these factors in HIV patients with good or poor CD4(+) T-cell recovery on long-term ART. Messenger RNA levels for 3 interferon-stimulated genes were increased in CD4(+) T cells of patients with poor CD4(+) T-cell recovery, whereas levels in patients with good recovery did not differ from those in healthy controls. Poor CD4(+) T-cell recovery was also associated with CD4(+) T-cell expression of markers of activation, senescence, and apoptosis, and with increased serum levels of the lipopolysaccharide receptor and soluble CD14, but these were not significantly correlated with expression of the interferon-stimulated genes. Therefore, CD4(+) T-cell recovery may be adversely affected by the effects of IFN-α, which may be amenable to therapeutic intervention.
大多数接受抗逆转录病毒治疗 (ART) 的人类免疫缺陷病毒 (HIV) 患者仍存在 CD4(+) T 细胞缺陷，这些患者表现出明显的免疫激活。由于 CD4(+) T 细胞的激活可能是由微生物易位或干扰素-α (IFN-α) 介导的，我们在长期接受 ART 治疗的 CD4(+) T 细胞恢复良好或不佳的 HIV 患者中检查了这些因素。在 CD4(+) T 细胞中，CD4(+) T 细胞恢复不佳的患者的 3 种干扰素刺激基因的信使 RNA 水平升高，而恢复良好的患者的水平与健康对照组没有差异。CD4(+) T 细胞恢复不佳也与 CD4(+) T 细胞的激活、衰老和凋亡标志物表达以及脂多糖受体和可溶性 CD14 的血清水平升高有关，但这些与干扰素刺激基因的表达没有显著相关性。因此，CD4(+) T 细胞的恢复可能会受到 IFN-α 的影响，这可能需要治疗干预。
