Rogers J H
Department of Physiology, University of Cambridge, UK.
FEBS Lett. 1990 Aug 1;268(2):339-43. doi: 10.1016/0014-5793(90)81282-s.
What are the roles of 'classical' introns in the evolution of nuclear genes, and what was the origin of these introns? Exon shuffling has been important in the evolution of cell surface and extracellular proteins, but the evidence for it in respect of intracellular proteins is weak. Intron distributions imply that some introns have been removed while others have been inserted in the course of evolution: ancestral patterns of introns may thus have been obscured. Recent evidence on the self-splicing and reverse-splicing abilities of Group II introns supports the hypothesis that these could have been the ancestors of classical introns.
“经典”内含子在核基因进化中扮演着怎样的角色，这些内含子的起源又是什么？外显子重排对于细胞表面蛋白和细胞外蛋白的进化十分重要，但在细胞内蛋白方面，其证据却很薄弱。内含子分布表明，在进化过程中一些内含子已被去除，而另一些则被插入：因此内含子的原始模式可能已被掩盖。关于II类内含子自我剪接和反向剪接能力的最新证据支持了这样一种假说，即这些内含子可能是经典内含子的祖先。
