Ganeshan Manisha, Sainath Pothaganti B, Padmavathi Inagadapa J Naga, Venu Lagishetty, Kishore Yedla Durga, Kumar Kalle Anand, Harishanker Nemani, Rao J Srinivasa, Raghunath Manchala
Division of Endocrinology and Metabolism, National Institute of Nutrition, Hyderabad 500 604, India.
Exp Diabetes Res. 2011;2011:486316. doi: 10.1155/2011/486316. Epub 2011 Oct 11.
Growth in utero is largely a reflection of nutrient and oxygen supply to the foetus. We studied the effects of Mn restriction per se, maternal Mn restriction, and postnatal high-fat feeding in modulating body composition, lipid metabolism and adipocyte function in Wistar/NIN (WNIN) rat offspring. Female weanling, WNIN rats received ad libitum for 4 months, a control or Mn-restricted diet and were mated with control males. Some restricted mothers were rehabilitated with control diet from conception (MnRC) or parturition (MnRP), and their offspring were raised on control diet. Some restricted offspring were weaned onto control diet (MnRW), while others continued on restricted diet throughout (MnR). A set of offspring from each group was fed high-fat diet from 9 months onwards. Body composition, adipocytes function, and lipid metabolism were monitored in male rat offspring at regular intervals. Maternal manganese restriction increased the susceptibility of the offspring to high-fat-induced adiposity, dyslipidaemia, and a proinflammatory state but did not affect their glycemic or insulin status.
子宫内的生长在很大程度上反映了向胎儿的营养和氧气供应情况。我们研究了锰限制本身、母体锰限制以及产后高脂喂养对Wistar/NIN（WNIN）大鼠后代身体组成、脂质代谢和脂肪细胞功能的调节作用。雌性断乳WNIN大鼠自由进食4个月，分别给予对照饮食或锰限制饮食，然后与对照雄性大鼠交配。一些受限制的母鼠在受孕时（MnRC）或分娩时（MnRP）恢复对照饮食，其后代用对照饮食饲养。一些受限制的后代断乳后改用对照饮食（MnRW），而另一些则一直持续食用限制饮食（MnR）。从每组中选取一组后代从9个月起喂食高脂饮食。定期监测雄性大鼠后代的身体组成、脂肪细胞功能和脂质代谢。母体锰限制增加了后代对高脂诱导的肥胖、血脂异常和促炎状态的易感性，但不影响其血糖或胰岛素状态。
