Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.
Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
BMC Public Health. 2020 Jun 5;20(1):874. doi: 10.1186/s12889-020-09011-x.
Manganese (Mn) participates in lipid metabolism. However, the associations between Mn exposure and dyslipidaemia is unclear.
This was a cross-sectional study. Data were collected from the 2017 the Mn-exposed workers healthy cohort (MEWHC). Finally, 803 occupationally Mn-exposed workers included in the study. The workers were divided into two groups. The grouping of this study was based on Mn-Time Weighted Averages (Mn-TWA). The high-exposure group included participants with Mn-TWA greater than 0.15 mg/m. The low-exposure group included participants with Mn-TWA less than or equal to 0.15 mg/m. Mn-TWA levels and dyslipidaemia were assessed.
After adjustment for seniority, sex, cigarette consumption, alcohol consumption, high-fat diet frequency, medicine intake in the past two weeks, egg intake frequency, drinking tea, WHR, and hypertension, Mn-TWA levels was negatively correlated with high triglycerides (TG) risk in workers overall (OR = 0.51; 95% CI: 0.36, 0.73; p < 0.01). The results of males and females were consistent (OR = 0.53; 95% CI: 0.34, 0.81; p < 0.01) and (OR = 0.47; 95% CI: 0.24, 0.94; p < 0.01), respectively. By performing interactions analyses of workers overall, we observed no significant interactions among confounders. Mn-TWA levels and pack-years on high TG risk (relative excess risk for the interactions (RERI = 2.29, 95% CI: - 2.07, 6.66), (RERI) = 2.98, 95% CI: - 2.30, 8.26). Similarly, smoking status, drinking status, high-fat diet frequency, and Waist-to-Hip Ratio (WHR) showed non-significant interactions with Mn-TWA levels on high TG risk.
This research indicates that high Mn exposure was negatively related to high TG risk in workers.
锰（Mn）参与脂质代谢。然而，Mn 暴露与血脂异常之间的关系尚不清楚。
这是一项横断面研究。数据来自 2017 年锰暴露工人健康队列（MEWHC）。最终纳入 803 名职业性 Mn 暴露工人。将工人分为两组。本研究的分组基于 Mn 时间加权平均值（Mn-TWA）。高暴露组包括 Mn-TWA 大于 0.15mg/m 的参与者。低暴露组包括 Mn-TWA 小于或等于 0.15mg/m 的参与者。评估 Mn-TWA 水平和血脂异常。
在校正工龄、性别、吸烟、饮酒、高脂肪饮食频率、过去两周服药、鸡蛋摄入频率、饮茶、腰臀比（WHR）和高血压后，Mn-TWA 水平与工人整体高甘油三酯（TG）风险呈负相关（OR=0.51；95%CI：0.36，0.73；p<0.01）。男性和女性的结果一致（OR=0.53；95%CI：0.34，0.81；p<0.01）和（OR=0.47；95%CI：0.24，0.94；p<0.01）。对所有工人进行交互作用分析，我们观察到混杂因素之间没有显著的交互作用。Mn-TWA 水平与高 TG 风险的吸烟年支数（相对超额交互作用风险（RERI）=2.29，95%CI：-2.07，6.66），（RERI）=2.98，95%CI：-2.30，8.26）。同样，吸烟状况、饮酒状况、高脂肪饮食频率和腰臀比（WHR）与高 TG 风险的 Mn-TWA 水平之间也没有显示出显著的交互作用。
本研究表明，高 Mn 暴露与工人高 TG 风险呈负相关。
