荚膜组织胞浆菌的毒力与宿主反应。
Histoplasma virulence and host responses.
作者信息
Mihu Mircea Radu, Nosanchuk Joshua Daniel
机构信息
Department of Medicine, Sound Shore Medical Center of Westchester, New Rochelle, NY 10802, USA.
出版信息
Int J Microbiol. 2012;2012:268123. doi: 10.1155/2012/268123. Epub 2011 Oct 5.
Abstract
Histoplasma capsulatum is the most prevalent cause of fungal respiratory disease. The disease extent and outcomes are the result of the complex interaction between the pathogen and a host's immune system. The focus of our paper consists in presenting the current knowledge regarding the multiple facets of the dynamic host-pathogen relationship in the context of the virulence arsenal displayed by the fungus and the innate and adaptive immune responses of the host.
摘要
荚膜组织胞浆菌是引起真菌性呼吸道疾病最常见的病因。疾病的严重程度和转归是病原体与宿主免疫系统复杂相互作用的结果。我们论文的重点在于，在真菌所展现的毒力武器库以及宿主的固有免疫和适应性免疫反应的背景下，介绍关于动态宿主 - 病原体关系多个方面的现有知识。
相似文献
1
Histoplasma virulence and host responses.荚膜组织胞浆菌的毒力与宿主反应。
Int J Microbiol. 2012;2012:268123. doi: 10.1155/2012/268123. Epub 2011 Oct 5.
2
Histoplasma capsulatum and Caenorhabditis elegans: a simple nematode model for an innate immune response to fungal infection.荚膜组织胞浆菌和秀丽隐杆线虫：固有免疫反应对真菌感染的一种简单线虫模型。
Med Mycol. 2009 Dec;47(8):808-13. doi: 10.3109/13693780802660532.
3
An Intracellular Arrangement of Histoplasma capsulatum Yeast-Aggregates Generates Nuclear Damage to the Cultured Murine Alveolar Macrophages.荚膜组织胞浆菌酵母聚集体的细胞内排列对培养的小鼠肺泡巨噬细胞造成核损伤。
Front Microbiol. 2016 Jan 11;6:1526. doi: 10.3389/fmicb.2015.01526. eCollection 2015.
4
Histoplasma capsulatum at the host-pathogen interface.宿主-病原体界面的荚膜组织胞浆菌
Microbes Infect. 2008 Jul;10(9):973-7. doi: 10.1016/j.micinf.2008.07.011. Epub 2008 Jul 10.
5
Conidia but not yeast cells of the fungal pathogen Histoplasma capsulatum trigger a type I interferon innate immune response in murine macrophages.真菌病原体荚膜组织胞浆菌的分生孢子而不是酵母细胞，会在鼠巨噬细胞中引发 I 型干扰素先天免疫反应。
Infect Immun. 2010 Sep;78(9):3871-82. doi: 10.1128/IAI.00204-10. Epub 2010 Jul 6.
6
Sensing the heat and the host: Virulence determinants of .感知热和宿主：.的毒力决定因素
Virulence. 2019 Dec;10(1):793-800. doi: 10.1080/21505594.2019.1663596.
7
Revisiting old friends: Developments in understanding Histoplasma capsulatum pathogenesis.重温旧识：荚膜组织胞浆菌致病机制研究进展
J Microbiol. 2016 Mar;54(3):265-76. doi: 10.1007/s12275-016-6044-5. Epub 2016 Feb 27.
8
Histoplasma capsulatum molecular genetics, pathogenesis, and responsiveness to its environment.荚膜组织胞浆菌的分子遗传学、发病机制及其对环境的反应。
Fungal Genet Biol. 2002 Mar;35(2):81-97. doi: 10.1006/fgbi.2001.1311.
9
Protective antibodies and endemic dimorphic fungi.保护性抗体与地方性双相真菌。
Curr Mol Med. 2005 Jun;5(4):435-42. doi: 10.2174/1566524054022530.
10
CD103+ Conventional Dendritic Cells Are Critical for TLR7/9-Dependent Host Defense against Histoplasma capsulatum, an Endemic Fungal Pathogen of Humans.CD103⁺传统树突状细胞对于TLR7/9依赖性宿主抵御荚膜组织胞浆菌（一种人类地方性真菌病原体）至关重要。
PLoS Pathog. 2016 Jul 26;12(7):e1005749. doi: 10.1371/journal.ppat.1005749. eCollection 2016 Jul.
引用本文的文献
1
Common virulence factors between and : Recognition of Hsp60 and Enolase by CR3 and plasmin receptors in host cells.[具体两种物质]之间的常见毒力因子：宿主细胞中CR3和纤溶酶受体对热休克蛋白60（Hsp60）和烯醇化酶的识别 。 （注：原文中“and”前后缺少具体指代内容）
Curr Res Microb Sci. 2024 Jun 8;7:100246. doi: 10.1016/j.crmicr.2024.100246. eCollection 2024.
2
Histoplasmosis Causing Overt Inflammation Presenting as Pericarditis: A Case Report.组织胞浆菌病引发明显炎症并表现为心包炎：一例报告
Cureus. 2024 May 2;16(5):e59512. doi: 10.7759/cureus.59512. eCollection 2024 May.
3
Unveiling the menace: a thorough review of potential pandemic fungal disease.揭示威胁：对潜在大流行性真菌病的全面综述
Front Fungal Biol. 2024 Apr 22;5:1338726. doi: 10.3389/ffunb.2024.1338726. eCollection 2024.
4
Design of a Multi-Epitope Vaccine against through Immunoinformatics Approaches.通过免疫信息学方法设计一种针对……的多表位疫苗。 （原文中against后缺少具体内容）
J Fungi (Basel). 2024 Jan 5;10(1):43. doi: 10.3390/jof10010043.
5
Immunomodulatory Potential of Fungal Extracellular Vesicles: Insights for Therapeutic Applications.真菌细胞外囊泡的免疫调节潜力：治疗应用的新视角。
Biomolecules. 2023 Oct 6;13(10):1487. doi: 10.3390/biom13101487.
6
The seroprevalence of anti-Histoplasma capsulatum IgG antibody among pulmonary tuberculosis patients in seven referral tuberculosis hospitals in Indonesia.印度尼西亚七家转诊结核病医院肺结核患者中抗荚膜组织胞浆菌 IgG 抗体的血清流行率。
PLoS Negl Trop Dis. 2023 Sep 20;17(9):e0011575. doi: 10.1371/journal.pntd.0011575. eCollection 2023 Sep.
7
Moonlighting proteins in medically relevant fungi.医学相关真菌中的兼职蛋白质。
PeerJ. 2022 Sep 13;10:e14001. doi: 10.7717/peerj.14001. eCollection 2022.
8
Infection: Virulence, Intracellular Lifestyle and Host Defense Mechanisms.感染：毒力、细胞内生存方式与宿主防御机制
J Fungi (Basel). 2022 Feb 19;8(2):200. doi: 10.3390/jof8020200.
9
Histoplasmosis in African children: clinical features, diagnosis and treatment.非洲儿童组织胞浆菌病：临床特征、诊断与治疗
Ther Adv Infect Dis. 2022 Jan 21;9:20499361211068592. doi: 10.1177/20499361211068592. eCollection 2022 Jan-Dec.
10
Interactions of Extracellular Vesicles from Pathogenic Fungi with Innate Leukocytes.致病真菌细胞外囊泡与固有免疫细胞的相互作用。
Curr Top Microbiol Immunol. 2021;432:89-120. doi: 10.1007/978-3-030-83391-6_9.
本文引用的文献
1
Discovery of a role for Hsp82 in Histoplasma virulence through a quantitative screen for macrophage lethality.通过定量筛选巨噬细胞致死性发现 Hsp82 在荚膜组织胞浆菌毒力中的作用。
Infect Immun. 2011 Aug;79(8):3348-57. doi: 10.1128/IAI.05124-11. Epub 2011 May 23.
2
Histoplasma capsulatum heat-shock 60 orchestrates the adaptation of the fungus to temperature stress.荚膜热休克蛋白 60 调控真菌适应温度胁迫。
PLoS One. 2011 Feb 10;6(2):e14660. doi: 10.1371/journal.pone.0014660.
3
Histoplasma capsulatum utilizes siderophores for intracellular iron acquisition in macrophages.荚膜组织胞浆菌利用铁载体在巨噬细胞内摄取铁。
Med Mycol. 2011 Aug;49(6):633-42. doi: 10.3109/13693786.2011.558930. Epub 2011 Feb 22.
4
Definition of the extracellular proteome of pathogenic-phase Histoplasma capsulatum.定义有性期荚膜组织胞浆菌细胞外蛋白质组。
J Proteome Res. 2011 Apr 1;10(4):1929-43. doi: 10.1021/pr1011697. Epub 2011 Feb 25.
5
Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice.疫苗诱导的对北美地方性 3 种系统性真菌感染的保护作用需要 Th17 细胞在小鼠中发挥作用。
J Clin Invest. 2011 Feb;121(2):554-68. doi: 10.1172/JCI43984. Epub 2011 Jan 4.
6
Agglutination of Histoplasma capsulatum by IgG monoclonal antibodies against Hsp60 impacts macrophage effector functions.免疫球蛋白 G 单克隆抗体对组织胞浆菌热休克蛋白 60 的凝集作用影响巨噬细胞效应功能。
Infect Immun. 2011 Feb;79(2):918-27. doi: 10.1128/IAI.00673-10. Epub 2010 Dec 6.
7
Metallomic analysis of macrophages infected with Histoplasma capsulatum reveals a fundamental role for zinc in host defenses.金属组学分析感染荚膜组织胞浆菌的巨噬细胞表明锌在宿主防御中的重要作用。
J Infect Dis. 2010 Oct 1;202(7):1136-45. doi: 10.1086/656191.
8
Interaction of pathogenic yeasts with phagocytes: survival, persistence and escape.致病酵母菌与吞噬细胞的相互作用：存活、持续存在和逃逸。
Curr Opin Microbiol. 2010 Aug;13(4):392-400. doi: 10.1016/j.mib.2010.05.001. Epub 2010 Jun 4.
9
CCR5 dictates the equilibrium of proinflammatory IL-17+ and regulatory Foxp3+ T cells in fungal infection.CCR5 决定真菌感染中促炎的 IL-17+ 和调节性 Foxp3+ T 细胞的平衡。
J Immunol. 2010 May 1;184(9):5224-31. doi: 10.4049/jimmunol.1000032. Epub 2010 Mar 24.
10
Antigen-presenting dendritic cells rescue CD4-depleted CCR2-/- mice from lethal Histoplasma capsulatum infection.树突状细胞呈递抗原可使耗尽 CD4 的 CCR2-/- 小鼠免于致死性荚膜组织胞浆菌感染。
Infect Immun. 2010 May;78(5):2125-37. doi: 10.1128/IAI.00065-10. Epub 2010 Mar 1.
Zotero 插件