Aesthetic and Plastic Surgery Institute, University of California, Irvine, Orange, CA 92868, USA.
Stem Cells Int. 2011;2011:619583. doi: 10.4061/2011/619583. Epub 2011 Oct 5.
During embryonic development pluripotency is progressively lost irreversibly by cell division, differentiation, migration and organ formation. Terminally differentiated cells do not generate other kinds of cells. Pluripotent stem cells are a great source of varying cell types that are used for tissue regeneration or repair of damaged tissue. The pluripotent stem cells can be derived from inner cell mass of blastocyte but its application is limited due to ethical concerns. The recent discovery of iPS with defined reprogramming factors has initiated a flurry of works on stem cell in various laboratories. The pluripotent cells can be derived from various differentiated adult cells as well as from adult stem cells by nuclear reprogramming, somatic cell nuclear transfer etc. In this review article, different aspects of nuclear reprogramming are discussed.
在胚胎发育过程中，多能性通过细胞分裂、分化、迁移和器官形成而不可逆转地逐渐丧失。终末分化细胞不能产生其他类型的细胞。多能干细胞是各种细胞类型的重要来源，可用于组织再生或修复受损组织。多能干细胞可以从胚泡的内细胞团中获得，但由于伦理问题，其应用受到限制。最近发现的具有明确重编程因子的 iPS 引发了各个实验室对干细胞的大量研究。多能细胞可以通过核重编程从各种分化的成体细胞以及成体干细胞中获得，如体细胞细胞核移植等。在这篇综述文章中，讨论了核重编程的不同方面。
