Wei Jinxiong, Zaika Elena, Zaika Alexander
Department of Surgery and Cancer Biology, Vanderbilt University Medical Center, 1255 Light Hall, 2215 Garland Avenue, Nashville, TN 37232, USA.
J Nucleic Acids. 2012;2012:687359. doi: 10.1155/2012/687359. Epub 2011 Oct 9.
TP53, TP63, and TP73 genes comprise the p53 family. Each gene produces protein isoforms through multiple mechanisms including extensive alternative mRNA splicing. Accumulating evidence shows that these isoforms play a critical role in the regulation of many biological processes in normal cells. Their abnormal expression contributes to tumorigenesis and has a profound effect on tumor response to curative therapy. This paper is an overview of isoform diversity in the p53 family and its role in cancer.
TP53、TP63和TP73基因组成了p53家族。每个基因通过多种机制产生蛋白质异构体，包括广泛的可变mRNA剪接。越来越多的证据表明，这些异构体在正常细胞中许多生物学过程的调节中起着关键作用。它们的异常表达促进肿瘤发生，并对肿瘤对根治性治疗的反应产生深远影响。本文概述了p53家族中的异构体多样性及其在癌症中的作用。
