Mahmoud Ghaniema Eiman, Fathi Ahmed Sahar, Raouf Amin Irene, Soliman Ayoub Maryse
Rheumatology and Rehabilitation Department, Ain Shams University, Cairo 11566, Egypt.
J Osteoporos. 2011;2011:106380. doi: 10.4061/2011/106380. Epub 2011 Oct 5.
Objective. To find out the presence of osteoporosis in hemophilic arthropathy patients and its correlation with clinical severity and serum levels of magnesium, copper, and zinc. Methods. Joint score, functional assessment score, bone densitometry, and serum magnesium, copper and zinc were done in twenty male hemophilic arthropathy patients and twenty controls. Results. There was highly significant lower Z scores of lumbar spine and neck of femur in patients versus controls (P < 0.011). Z score of neck of femur correlated negatively with total joint score (P = 0.013) and functional assessment score (P = 0.011). Serum levels of copper and zinc correlated positively with Z score of neck of femur (P = 0.004, P = 0.001, resp.). Conclusion. Osteoporosis represents a frequent concomitant observation in hemophiliacs. Screening of young hemophiliacs for osteoporosis is recommended with measuring serum levels of magnesium, copper, and zinc for better management of the disease.
目的。探讨血友病性关节病患者骨质疏松的存在情况及其与临床严重程度以及血清镁、铜和锌水平的相关性。方法。对20名男性血友病性关节病患者和20名对照者进行关节评分、功能评估评分、骨密度测定以及血清镁、铜和锌检测。结果。与对照组相比，患者腰椎和股骨颈的Z值显著更低（P < 0.011）。股骨颈的Z值与总关节评分呈负相关（P = 0.013），与功能评估评分呈负相关（P = 0.011）。血清铜和锌水平与股骨颈的Z值呈正相关（分别为P = 0.004，P = 0.001）。结论。骨质疏松是血友病患者常见的伴随表现。建议对年轻血友病患者进行骨质疏松筛查，并检测血清镁、铜和锌水平，以更好地管理该疾病。
