地锦草根部的蒽醌类化合物。

Anthraquinones from the roots of Knoxia valerianoides.

作者信息

Zhao Feng, Wang Su-Juan, Lin Sheng, Zhu Cheng-Gen, Yuan Shao-Peng, Ding Xiao-Yu, Yue Zheng-Gang, Yu Yang, Liu Bo, Wu Xiu-Li, Hou Qi, Shi Jian-Gong

机构信息

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, and Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.

出版信息

J Asian Nat Prod Res. 2011 Oct;13(11):1023-9. doi: 10.1080/10286020.2011.606813. Epub 2011 Oct 19.

DOI:10.1080/10286020.2011.606813

PMID:22007602

Abstract

Five new 9,10-anthraquinones (1-5) were isolated from an ethanol extract of the roots of Knoxia valerianoides. Their structures including absolute configuration of 1 were determined by spectroscopic analysis. Compounds 4 and 5 showed moderate activity against nitrogen oxide production in macrophages induced by lipopolysaccharide, at 10(- 5) M, with inhibition ratios of 50.4 ± 3.6 and 41.7 ± 2.1%, respectively.

摘要

从水金凤的根部乙醇提取物中分离出五种新的9,10-蒽醌（1-5）。通过光谱分析确定了它们的结构，包括1的绝对构型。化合物4和5在10（-5）M浓度下，对脂多糖诱导的巨噬细胞中一氧化氮的产生表现出中等活性，抑制率分别为50.4±3.6%和41.7±2.1%。