Guerin J F, Ben Ali H, Cottinet D, Rollet J
Laboratoire de Biologie de la Reproduction, Service du Professeur J. C.Czyba, Hôpital Edouard-Herriot Place d'Arsonval, Lyon, France.
J Androl. 1990 May-Jun;11(3):240-5.
Glucosidase (alpha G) activity was measured in sperm free seminal plasma from 1200 patients consulting for primary infertility, in whom clinical examination of epididymides revealed some abnormalities and histories of genital infections. They constituted the group with epididymal pathology (P) that was compared with a reference group (R) of 246 men without any epididymal pathology. The distribution of alpha G was significantly different between the two groups, even if we considered only the subjects in group P with normal sperm count (PN: 353 men: p less than 10(-6). 15.9% of subjects in group PN exhibited alpha G values as low as vasectomized men, versus 1.2% in group R. A linear relationship was established between alpha G and sperm content in both groups, but alpha G activities were systematically lower in group P (y = 0.19 x + 64) than in group R (y = 0.30 x + 86). There was no correlation between alpha G and the percent of sperm motility. On the contrary, we found statistically more clinical epididymal abnormalities in cases of decreased alpha G activity than in cases of normal alpha G activity (p less than .01).
对1200名因原发性不育前来咨询的患者的无精子精浆中的葡萄糖苷酶（αG）活性进行了测定。这些患者的附睾临床检查显示存在一些异常情况且有生殖器感染史。他们构成了附睾病理组（P组），并与246名无任何附睾病理的男性组成的参照组（R组）进行比较。即使仅考虑P组中精子计数正常的受试者（PN组：353名男性，p＜10⁻⁶），两组间αG的分布也存在显著差异。PN组中15.9%的受试者αG值低至输精管结扎男性的水平，而R组中这一比例为1.2%。两组中αG与精子含量之间均建立了线性关系，但P组（y = 0.19x + 64）的αG活性系统性地低于R组（y = 0.30x + 86）。αG与精子活力百分比之间无相关性。相反，我们发现αG活性降低的病例中，临床附睾异常在统计学上比αG活性正常的病例更多（p＜0.01）。
