Elzanaty Saad
Scanian Andrology Centre, Fertility Centre, Malmö University Hospital, Lund University, Malmö, Sweden.
Arch Androl. 2007 May-Jun;53(3):149-56. doi: 10.1080/01485010701225667.
Increased male age has been associated with significant reduction in pregnancy rates. This study investigated the association between age, the function of epididymal and accessory sex glands, and their relation to sperm motility. Ejaculates from 498 men assessed for infertility were analysed according to WHO [1999] guidelines. Seminal markers of epididymal (neutral alpha-glucosidase (NAG)), prostatic (prostate-specific antigen (PSA) and zinc), and seminal vesicle function (fructose) were measured. Four groups according to age were defined: G(21-30) (21-30 years), G(31-40) (31-40 years), G(41-50) (41-50 years), and G(>50) (51-66 years). Percentage progressive motility was significantly lower in G(>50) compared with G(21-30). NAG, PSA, zinc, and fructose were significantly lower in G(>50) compared with G(21-30). In a multiple regression analysis model, NAG and PSA showed positive significant association with percentage progressive motility. The opposite trend was found regarding zinc. No association between fructose and percentage progressive motility was shown. In this cross-sectional study, declined sperm motility observed in men over 50 years of age might be due to age-dependent changes in epididymal and accessory sex gland function.
男性年龄增加与妊娠率显著降低有关。本研究调查了年龄、附睾及附属性腺功能之间的关联及其与精子活力的关系。根据世界卫生组织[1999]指南，对498名接受不育评估的男性的射精样本进行了分析。检测了附睾（中性α-葡萄糖苷酶（NAG））、前列腺（前列腺特异性抗原（PSA）和锌）以及精囊功能（果糖）的精液标志物。根据年龄分为四组：G(21 - 30)（21 - 30岁）、G(31 - 40)（31 - 40岁）、G(41 - 50)（41 - 50岁）和G(>50)（51 - 66岁）。与G(21 - 30)组相比，G(>50)组的进行性运动百分比显著降低。与G(21 - 30)组相比，G(>50)组的NAG、PSA、锌和果糖显著降低。在多元回归分析模型中，NAG和PSA与进行性运动百分比呈显著正相关。锌则呈现相反趋势。未显示果糖与进行性运动百分比之间存在关联。在这项横断面研究中，50岁以上男性观察到的精子活力下降可能是由于附睾和附属性腺功能随年龄变化所致。
